| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cav1 | csk | ENSDARP00000141857 | ENSDARP00000088849 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Tyrosine-protein kinase. | 0.690 |
| cav1 | ctnnb1 | ENSDARP00000141857 | ENSDARP00000139205 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.738 |
| cav1 | egfra | ENSDARP00000141857 | ENSDARP00000125265 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Epidermal growth factor receptor precursor. | 0.818 |
| cav1 | itgb1a | ENSDARP00000141857 | ENSDARP00000039699 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Integrin beta; Belongs to the integrin beta chain family. | 0.758 |
| cav1 | itgb1b | ENSDARP00000141857 | ENSDARP00000137182 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Integrin beta; Belongs to the integrin beta chain family. | 0.762 |
| cav1 | ptk2ab | ENSDARP00000141857 | ENSDARP00000042715 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.543 |
| cav1 | pxnb | ENSDARP00000141857 | ENSDARP00000080428 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. | 0.641 |
| cav1 | src | ENSDARP00000141857 | ENSDARP00000093618 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.980 |
| cav1 | stat3 | ENSDARP00000141857 | ENSDARP00000095292 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Signal transducer and activator of transcription. | 0.453 |
| cav1 | tjp1a | ENSDARP00000141857 | ENSDARP00000156719 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Tight junction protein 1a; Belongs to the MAGUK family. | 0.473 |
| csk | cav1 | ENSDARP00000088849 | ENSDARP00000141857 | Tyrosine-protein kinase. | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | 0.690 |
| csk | ctnnb1 | ENSDARP00000088849 | ENSDARP00000139205 | Tyrosine-protein kinase. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.425 |
| csk | egfra | ENSDARP00000088849 | ENSDARP00000125265 | Tyrosine-protein kinase. | Epidermal growth factor receptor precursor. | 0.838 |
| csk | ptk2ab | ENSDARP00000088849 | ENSDARP00000042715 | Tyrosine-protein kinase. | Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.691 |
| csk | pxnb | ENSDARP00000088849 | ENSDARP00000080428 | Tyrosine-protein kinase. | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. | 0.945 |
| csk | src | ENSDARP00000088849 | ENSDARP00000093618 | Tyrosine-protein kinase. | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.972 |
| ctnnb1 | cav1 | ENSDARP00000139205 | ENSDARP00000141857 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | 0.738 |
| ctnnb1 | csk | ENSDARP00000139205 | ENSDARP00000088849 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Tyrosine-protein kinase. | 0.425 |
| ctnnb1 | egfra | ENSDARP00000139205 | ENSDARP00000125265 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Epidermal growth factor receptor precursor. | 0.987 |
| ctnnb1 | itgb1a | ENSDARP00000139205 | ENSDARP00000039699 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Integrin beta; Belongs to the integrin beta chain family. | 0.526 |
STRING v12.5 is now available!
