node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSDARP00000142481 | X1WHF1_DANRE | ENSDARP00000142481 | ENSDARP00000129663 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone H2B; Belongs to the histone H2B family. | 0.947 |
ENSDARP00000142481 | h3f3a-2 | ENSDARP00000142481 | ENSDARP00000089753 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] | 0.967 |
ENSDARP00000142481 | hist1h2a3 | ENSDARP00000142481 | ENSDARP00000093780 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone H2A; Belongs to the histone H2A family. | 0.954 |
ENSDARP00000142481 | hist2h2l | ENSDARP00000142481 | ENSDARP00000055912 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.947 |
ENSDARP00000142481 | zgc:113983 | ENSDARP00000142481 | ENSDARP00000084277 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.967 |
ENSDARP00000142481 | zgc:173552 | ENSDARP00000142481 | ENSDARP00000067896 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | Histone H3; Belongs to the histone H3 family. | 0.967 |
X1WHF1_DANRE | ENSDARP00000142481 | ENSDARP00000129663 | ENSDARP00000142481 | Histone H2B; Belongs to the histone H2B family. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.947 |
X1WHF1_DANRE | aebp2 | ENSDARP00000129663 | ENSDARP00000022060 | Histone H2B; Belongs to the histone H2B family. | Zinc finger protein AEBP2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of histone methyltransferase complexes. | 0.684 |
X1WHF1_DANRE | h3f3a-2 | ENSDARP00000129663 | ENSDARP00000089753 | Histone H2B; Belongs to the histone H2B family. | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] | 0.968 |
X1WHF1_DANRE | hist1h2a3 | ENSDARP00000129663 | ENSDARP00000093780 | Histone H2B; Belongs to the histone H2B family. | Histone H2A; Belongs to the histone H2A family. | 0.999 |
X1WHF1_DANRE | hist1h4l | ENSDARP00000129663 | ENSDARP00000077832 | Histone H2B; Belongs to the histone H2B family. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.947 |
X1WHF1_DANRE | hist2h2l | ENSDARP00000129663 | ENSDARP00000055912 | Histone H2B; Belongs to the histone H2B family. | Histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.405 |
X1WHF1_DANRE | rnf2 | ENSDARP00000129663 | ENSDARP00000002609 | Histone H2B; Belongs to the histone H2B family. | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin he [...] | 0.676 |
X1WHF1_DANRE | zgc:113983 | ENSDARP00000129663 | ENSDARP00000084277 | Histone H2B; Belongs to the histone H2B family. | Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.961 |
X1WHF1_DANRE | zgc:173552 | ENSDARP00000129663 | ENSDARP00000067896 | Histone H2B; Belongs to the histone H2B family. | Histone H3; Belongs to the histone H3 family. | 0.961 |
aebp2 | X1WHF1_DANRE | ENSDARP00000022060 | ENSDARP00000129663 | Zinc finger protein AEBP2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of histone methyltransferase complexes. | Histone H2B; Belongs to the histone H2B family. | 0.684 |
aebp2 | h3f3a-2 | ENSDARP00000022060 | ENSDARP00000089753 | Zinc finger protein AEBP2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of histone methyltransferase complexes. | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] | 0.769 |
aebp2 | hist1h2a3 | ENSDARP00000022060 | ENSDARP00000093780 | Zinc finger protein AEBP2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of histone methyltransferase complexes. | Histone H2A; Belongs to the histone H2A family. | 0.924 |
aebp2 | hist2h2l | ENSDARP00000022060 | ENSDARP00000055912 | Zinc finger protein AEBP2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of histone methyltransferase complexes. | Histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.667 |
aebp2 | rnf2 | ENSDARP00000022060 | ENSDARP00000002609 | Zinc finger protein AEBP2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of histone methyltransferase complexes. | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin he [...] | 0.884 |