STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa)    
Predicted Functional Partners:
pdgfaa
Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family.
    
 0.999
ENSDARP00000135075
Platelet-derived growth factor alpha polypeptide a.
    
 
 0.986
pdgfbb
Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family.
   
 0.978
egfra
Epidermal growth factor receptor precursor.
   
 0.974
pdgfba
Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family.
   
 0.972
pdgfab
Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family.
    
 0.970
pdgfc
Platelet-derived growth factor c; Belongs to the PDGF/VEGF growth factor family.
    
 0.948
ins
Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
   
 
 0.947
insb
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
   
 
 0.946
grb2b
Growth factor receptor-bound protein 2b.
   
 0.946
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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