STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
srgap2SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. May play a role in different aspects of neuronal morphogenesis and migration. This includes the biogenesis of neurites, where it could be required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. May also stimulate the branching of the leading process and negatively regulates neuron migration. In non-neuronal cells, it may also play a role in cell migration by reg [...] (1100 aa)    
Predicted Functional Partners:
itsn2a
Intersectin 2a.
   
0.752
atad2
ATPase family AAA domain-containing 2.
   
  
 0.678
BOLA2
Zgc:112271 protein; Belongs to the BolA/IbaG family.
      
 0.665
cdk11b
Cyclin-dependent kinase 11B.
   
  
 0.656
ddx43
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43; Belongs to the DEAD box helicase family.
   
  
 0.646
rac1a
Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1).
   
 0.646
sgsm2
Small G protein-signaling modulator 2.
      
 0.645
cdc42
Cell division cycle 42.
   
 
 0.638
rhoab
Rho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
    
 
 0.620
cdc42l2
Cell division cycle 42-like 2.
   
 0.609
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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