STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dkk3bDickkopf WNT-signaling pathway inhibitor 3b. (283 aa)    
Predicted Functional Partners:
dkk2
Dickkopf WNT-signaling pathway inhibitor 2.
   
  
 0.858
sfrp1a
Secreted frizzled-related protein 1a.
      
 0.826
dkk1b
Dickkopf WNT-signaling pathway inhibitor 1b.
      
 0.823
sfrp5
Secreted frizzled-related protein 5.
      
 0.822
dkk1a
Dickkopf WNT-signaling pathway inhibitor 1a.
      
 0.737
wif1
Wnt inhibitory factor 1; Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
   
  
 0.735
kremen1
Kringle-containing transmembrane protein 1.
    
 
 0.712
sfrp2
Secreted frizzled-related protein 2.
      
 0.702
ctnnb1
Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...]
   
 
 0.672
lrp5
Low density lipoprotein receptor-related protein 5.
    
 
 0.650
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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