node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ctnnb1 | dkk1a | ENSDARP00000139205 | ENSDARP00000017197 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Dickkopf WNT-signaling pathway inhibitor 1a. | 0.776 |
ctnnb1 | dkk1b | ENSDARP00000139205 | ENSDARP00000066476 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Dickkopf WNT-signaling pathway inhibitor 1b. | 0.960 |
ctnnb1 | dkk2 | ENSDARP00000139205 | ENSDARP00000098754 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Dickkopf WNT-signaling pathway inhibitor 2. | 0.811 |
ctnnb1 | dkk3b | ENSDARP00000139205 | ENSDARP00000094818 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Dickkopf WNT-signaling pathway inhibitor 3b. | 0.672 |
ctnnb1 | kremen1 | ENSDARP00000139205 | ENSDARP00000085117 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Kringle-containing transmembrane protein 1. | 0.528 |
ctnnb1 | lrp5 | ENSDARP00000139205 | ENSDARP00000108864 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Low density lipoprotein receptor-related protein 5. | 0.992 |
ctnnb1 | sfrp1a | ENSDARP00000139205 | ENSDARP00000051490 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Secreted frizzled-related protein 1a. | 0.775 |
ctnnb1 | sfrp2 | ENSDARP00000139205 | ENSDARP00000093275 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Secreted frizzled-related protein 2. | 0.767 |
ctnnb1 | sfrp5 | ENSDARP00000139205 | ENSDARP00000056995 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Secreted frizzled-related protein 5. | 0.823 |
ctnnb1 | wif1 | ENSDARP00000139205 | ENSDARP00000019818 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Wnt inhibitory factor 1; Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. | 0.703 |
dkk1a | ctnnb1 | ENSDARP00000017197 | ENSDARP00000139205 | Dickkopf WNT-signaling pathway inhibitor 1a. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.776 |
dkk1a | dkk1b | ENSDARP00000017197 | ENSDARP00000066476 | Dickkopf WNT-signaling pathway inhibitor 1a. | Dickkopf WNT-signaling pathway inhibitor 1b. | 0.905 |
dkk1a | dkk2 | ENSDARP00000017197 | ENSDARP00000098754 | Dickkopf WNT-signaling pathway inhibitor 1a. | Dickkopf WNT-signaling pathway inhibitor 2. | 0.933 |
dkk1a | dkk3b | ENSDARP00000017197 | ENSDARP00000094818 | Dickkopf WNT-signaling pathway inhibitor 1a. | Dickkopf WNT-signaling pathway inhibitor 3b. | 0.737 |
dkk1a | kremen1 | ENSDARP00000017197 | ENSDARP00000085117 | Dickkopf WNT-signaling pathway inhibitor 1a. | Kringle-containing transmembrane protein 1. | 0.895 |
dkk1a | lrp5 | ENSDARP00000017197 | ENSDARP00000108864 | Dickkopf WNT-signaling pathway inhibitor 1a. | Low density lipoprotein receptor-related protein 5. | 0.998 |
dkk1a | sfrp1a | ENSDARP00000017197 | ENSDARP00000051490 | Dickkopf WNT-signaling pathway inhibitor 1a. | Secreted frizzled-related protein 1a. | 0.575 |
dkk1a | sfrp2 | ENSDARP00000017197 | ENSDARP00000093275 | Dickkopf WNT-signaling pathway inhibitor 1a. | Secreted frizzled-related protein 2. | 0.628 |
dkk1a | sfrp5 | ENSDARP00000017197 | ENSDARP00000056995 | Dickkopf WNT-signaling pathway inhibitor 1a. | Secreted frizzled-related protein 5. | 0.517 |
dkk1a | wif1 | ENSDARP00000017197 | ENSDARP00000019818 | Dickkopf WNT-signaling pathway inhibitor 1a. | Wnt inhibitory factor 1; Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. | 0.769 |