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opa1 protein (Danio rerio) - STRING interaction network
"opa1" - Dynamin-like 120 kDa protein, mitochondrial in Danio rerio
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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opa1Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity) (966 aa)    
Predicted Functional Partners:
mfn2
Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family (757 aa)
     
 
  0.874
FIS1
Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (155 aa)
     
 
  0.787
pink1
PTEN induced putative kinase 1 (574 aa)
     
 
  0.749
park2
E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily (176 aa)
       
 
  0.735
ENSDARG00000079219
Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family (321 aa)
     
 
  0.699
mff
Mitochondrial fission factor homolog B; Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (By similarity) (344 aa)
     
 
  0.698
ENSDARG00000005121
Mitofusin 1b (420 aa)
     
 
  0.695
sirt3
NAD-dependent protein deacetylase; NAD-dependent protein deacetylase (357 aa)
     
 
  0.669
LOC792889
Presenilins-associated rhomboid-like protein, mitochondrial; Presenilin associated, rhomboid-like (334 aa)
     
 
  0.652
immt
MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (757 aa)
     
 
  0.648
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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