STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gamtGuanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. (234 aa)    
Predicted Functional Partners:
gatm
Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity).
   
 0.995
ckmt1
Creatine kinase, mitochondrial 1; Belongs to the ATP:guanido phosphotransferase family.
   
 
 0.951
ckbb
Brain-subtype creatine kinase; Belongs to the ATP:guanido phosphotransferase family.
   
 
 0.950
ckmb
Creatine kinase, muscle b; Belongs to the ATP:guanido phosphotransferase family.
   
 
 0.927
ckma
Creatine kinase, muscle a; Belongs to the ATP:guanido phosphotransferase family.
   
 
 0.923
ckba
Creatine kinase, brain a; Belongs to the ATP:guanido phosphotransferase family.
   
 
 0.922
ckmt2b
Creatine kinase, mitochondrial 2b (sarcomeric); Belongs to the ATP:guanido phosphotransferase family.
   
 
 0.921
ckmt2a
Creatine kinase, mitochondrial 2a (sarcomeric); Belongs to the ATP:guanido phosphotransferase family.
   
 
 0.921
gtpbp4
Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
   
    0.798
bxdc2
Brix domain-containing 2.
   
    0.793
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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