node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
bmi1b | cbx2 | ENSDARP00000115422 | ENSDARP00000066052 | Polycomb complex protein BMI-1-B; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2 (By similarity). | Chromobox homolog 2 (Drosophila Pc class). | 0.903 |
bmi1b | cbx6a | ENSDARP00000115422 | ENSDARP00000095582 | Polycomb complex protein BMI-1-B; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2 (By similarity). | Chromobox homolog 6a. | 0.906 |
bmi1b | cbx7b | ENSDARP00000115422 | ENSDARP00000108294 | Polycomb complex protein BMI-1-B; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2 (By similarity). | Chromobox homolog 7b. | 0.943 |
bmi1b | cbx8b | ENSDARP00000115422 | ENSDARP00000129929 | Polycomb complex protein BMI-1-B; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2 (By similarity). | Chromobox homolog 8b. | 0.983 |
bmi1b | eed | ENSDARP00000115422 | ENSDARP00000131820 | Polycomb complex protein BMI-1-B; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2 (By similarity). | Polycomb protein eed; Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). | 0.900 |
bmi1b | pcgf5a | ENSDARP00000115422 | ENSDARP00000095486 | Polycomb complex protein BMI-1-B; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2 (By similarity). | Polycomb group RING finger protein 5-A; Component of Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes. | 0.863 |
bmi1b | phc1 | ENSDARP00000115422 | ENSDARP00000058495 | Polycomb complex protein BMI-1-B; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2 (By similarity). | Polyhomeotic homolog 1. | 0.864 |
bmi1b | phc2a | ENSDARP00000115422 | ENSDARP00000054361 | Polycomb complex protein BMI-1-B; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2 (By similarity). | Polyhomeotic-like protein 2; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). | 0.973 |
bmi1b | phc2b | ENSDARP00000115422 | ENSDARP00000018055 | Polycomb complex protein BMI-1-B; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2 (By similarity). | Polyhomeotic homolog 2b (Drosophila). | 0.941 |
bmi1b | rnf2 | ENSDARP00000115422 | ENSDARP00000002609 | Polycomb complex protein BMI-1-B; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2 (By similarity). | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin he [...] | 0.998 |
cbx2 | bmi1b | ENSDARP00000066052 | ENSDARP00000115422 | Chromobox homolog 2 (Drosophila Pc class). | Polycomb complex protein BMI-1-B; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2 (By similarity). | 0.903 |
cbx2 | cbx6a | ENSDARP00000066052 | ENSDARP00000095582 | Chromobox homolog 2 (Drosophila Pc class). | Chromobox homolog 6a. | 0.740 |
cbx2 | cbx7b | ENSDARP00000066052 | ENSDARP00000108294 | Chromobox homolog 2 (Drosophila Pc class). | Chromobox homolog 7b. | 0.750 |
cbx2 | cbx8b | ENSDARP00000066052 | ENSDARP00000129929 | Chromobox homolog 2 (Drosophila Pc class). | Chromobox homolog 8b. | 0.812 |
cbx2 | eed | ENSDARP00000066052 | ENSDARP00000131820 | Chromobox homolog 2 (Drosophila Pc class). | Polycomb protein eed; Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). | 0.836 |
cbx2 | pcgf5a | ENSDARP00000066052 | ENSDARP00000095486 | Chromobox homolog 2 (Drosophila Pc class). | Polycomb group RING finger protein 5-A; Component of Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes. | 0.845 |
cbx2 | phc1 | ENSDARP00000066052 | ENSDARP00000058495 | Chromobox homolog 2 (Drosophila Pc class). | Polyhomeotic homolog 1. | 0.931 |
cbx2 | phc2a | ENSDARP00000066052 | ENSDARP00000054361 | Chromobox homolog 2 (Drosophila Pc class). | Polyhomeotic-like protein 2; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). | 0.942 |
cbx2 | phc2b | ENSDARP00000066052 | ENSDARP00000018055 | Chromobox homolog 2 (Drosophila Pc class). | Polyhomeotic homolog 2b (Drosophila). | 0.841 |
cbx2 | rnf2 | ENSDARP00000066052 | ENSDARP00000002609 | Chromobox homolog 2 (Drosophila Pc class). | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin he [...] | 0.993 |