node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cdc73 | eepd1 | ENSDARP00000129750 | ENSDARP00000095703 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | Endonuclease/exonuclease/phosphatase family domain-containing protein 1. | 0.744 |
cdc73 | iws1 | ENSDARP00000129750 | ENSDARP00000111339 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | TFIIS N-terminal domain-containing protein. | 0.726 |
cdc73 | leo1 | ENSDARP00000129750 | ENSDARP00000072160 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development. | 0.999 |
cdc73 | polr2d | ENSDARP00000129750 | ENSDARP00000099022 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | Polymerase (RNA) II (DNA directed) polypeptide D. | 0.876 |
cdc73 | polr2gl | ENSDARP00000129750 | ENSDARP00000073018 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | DNA-directed RNA polymerase II subunit RPB7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems [...] | 0.912 |
cdc73 | supt16h | ENSDARP00000129750 | ENSDARP00000111043 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | SPT16 homolog, facilitates chromatin-remodeling subunit. | 0.998 |
cdc73 | supt4h1 | ENSDARP00000129750 | ENSDARP00000147232 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | Transcription elongation factor SPT4; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development (By similarity). | 0.988 |
cdc73 | supt5h | ENSDARP00000129750 | ENSDARP00000062675 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | Transcription elongation factor SPT5; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development. Belongs to the SPT [...] | 0.995 |
eepd1 | cdc73 | ENSDARP00000095703 | ENSDARP00000129750 | Endonuclease/exonuclease/phosphatase family domain-containing protein 1. | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | 0.744 |
eepd1 | exo1 | ENSDARP00000095703 | ENSDARP00000073846 | Endonuclease/exonuclease/phosphatase family domain-containing protein 1. | Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity). | 0.761 |
eepd1 | iws1 | ENSDARP00000095703 | ENSDARP00000111339 | Endonuclease/exonuclease/phosphatase family domain-containing protein 1. | TFIIS N-terminal domain-containing protein. | 0.852 |
eepd1 | leo1 | ENSDARP00000095703 | ENSDARP00000072160 | Endonuclease/exonuclease/phosphatase family domain-containing protein 1. | RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development. | 0.918 |
eepd1 | polr2d | ENSDARP00000095703 | ENSDARP00000099022 | Endonuclease/exonuclease/phosphatase family domain-containing protein 1. | Polymerase (RNA) II (DNA directed) polypeptide D. | 0.771 |
eepd1 | polr2gl | ENSDARP00000095703 | ENSDARP00000073018 | Endonuclease/exonuclease/phosphatase family domain-containing protein 1. | DNA-directed RNA polymerase II subunit RPB7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems [...] | 0.781 |
eepd1 | shisa3 | ENSDARP00000095703 | ENSDARP00000102069 | Endonuclease/exonuclease/phosphatase family domain-containing protein 1. | Shisa family member 3. | 0.837 |
eepd1 | supt16h | ENSDARP00000095703 | ENSDARP00000111043 | Endonuclease/exonuclease/phosphatase family domain-containing protein 1. | SPT16 homolog, facilitates chromatin-remodeling subunit. | 0.833 |
eepd1 | supt4h1 | ENSDARP00000095703 | ENSDARP00000147232 | Endonuclease/exonuclease/phosphatase family domain-containing protein 1. | Transcription elongation factor SPT4; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development (By similarity). | 0.829 |
eepd1 | supt5h | ENSDARP00000095703 | ENSDARP00000062675 | Endonuclease/exonuclease/phosphatase family domain-containing protein 1. | Transcription elongation factor SPT5; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development. Belongs to the SPT [...] | 0.845 |
exo1 | eepd1 | ENSDARP00000073846 | ENSDARP00000095703 | Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity). | Endonuclease/exonuclease/phosphatase family domain-containing protein 1. | 0.761 |
iws1 | cdc73 | ENSDARP00000111339 | ENSDARP00000129750 | TFIIS N-terminal domain-containing protein. | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | 0.726 |