| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSDARP00000149604 | cul4a | ENSDARP00000149604 | ENSDARP00000131646 | Uncharacterized protein. | Cullin 4A; Belongs to the cullin family. | 0.953 |
| ENSDARP00000149604 | rnaseh2b | ENSDARP00000149604 | ENSDARP00000006173 | Uncharacterized protein. | Ribonuclease H2, subunit B. | 0.477 |
| ENSDARP00000149604 | samhd1 | ENSDARP00000149604 | ENSDARP00000096087 | Uncharacterized protein. | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...] | 0.840 |
| ENSDARP00000149604 | serinc5 | ENSDARP00000149604 | ENSDARP00000087966 | Uncharacterized protein. | Serine incorporator 5; Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids (By similarity). Belongs to the TDE1 family. | 0.406 |
| cul4a | ENSDARP00000149604 | ENSDARP00000131646 | ENSDARP00000149604 | Cullin 4A; Belongs to the cullin family. | Uncharacterized protein. | 0.953 |
| cul4a | samhd1 | ENSDARP00000131646 | ENSDARP00000096087 | Cullin 4A; Belongs to the cullin family. | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...] | 0.535 |
| dctpp1 | samhd1 | ENSDARP00000070991 | ENSDARP00000096087 | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...] | 0.599 |
| ifnphi1 | samhd1 | ENSDARP00000033132 | ENSDARP00000096087 | Interferon phi 1. | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...] | 0.545 |
| pex11g | samhd1 | ENSDARP00000149350 | ENSDARP00000096087 | Peroxisomal biogenesis factor 11 gamma. | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...] | 0.564 |
| rnaseh2a | rnaseh2b | ENSDARP00000045893 | ENSDARP00000006173 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Ribonuclease H2, subunit B. | 0.999 |
| rnaseh2a | rnaseh2c | ENSDARP00000045893 | ENSDARP00000123155 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Ribonuclease H2, subunit C. | 0.999 |
| rnaseh2a | samhd1 | ENSDARP00000045893 | ENSDARP00000096087 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...] | 0.954 |
| rnaseh2b | ENSDARP00000149604 | ENSDARP00000006173 | ENSDARP00000149604 | Ribonuclease H2, subunit B. | Uncharacterized protein. | 0.477 |
| rnaseh2b | rnaseh2a | ENSDARP00000006173 | ENSDARP00000045893 | Ribonuclease H2, subunit B. | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.999 |
| rnaseh2b | rnaseh2c | ENSDARP00000006173 | ENSDARP00000123155 | Ribonuclease H2, subunit B. | Ribonuclease H2, subunit C. | 0.999 |
| rnaseh2b | samhd1 | ENSDARP00000006173 | ENSDARP00000096087 | Ribonuclease H2, subunit B. | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...] | 0.833 |
| rnaseh2c | rnaseh2a | ENSDARP00000123155 | ENSDARP00000045893 | Ribonuclease H2, subunit C. | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.999 |
| rnaseh2c | rnaseh2b | ENSDARP00000123155 | ENSDARP00000006173 | Ribonuclease H2, subunit C. | Ribonuclease H2, subunit B. | 0.999 |
| rnaseh2c | samhd1 | ENSDARP00000123155 | ENSDARP00000096087 | Ribonuclease H2, subunit C. | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...] | 0.940 |
| samhd1 | ENSDARP00000149604 | ENSDARP00000096087 | ENSDARP00000149604 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...] | Uncharacterized protein. | 0.840 |