STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
oaz1aOrnithine decarboxylase antizyme 1; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin- independent proteolytic destruction by the 26S proteasome. (214 aa)    
Predicted Functional Partners:
odc1
Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family.
    
 0.988
azin1b
Antizyme inhibitor 1b; Belongs to the Orn/Lys/Arg decarboxylase class-II family.
   
 0.941
azin1a
Antizyme inhibitor 1a; Belongs to the Orn/Lys/Arg decarboxylase class-II family.
    
 
 0.927
tlcd4b
TLC domain-containing protein 4-B.
      
 0.840
ddx59
DEAD (Asp-Glu-Ala-Asp) box polypeptide 59.
   
  
 0.759
eef1g
Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components.
   
  
 0.706
dot1l
Histone-lysine N-methyltransferase, H3 lysine-79 specific.
   
  
 0.688
rpl27
60S ribosomal protein L27; Component of the large ribosomal subunit.
   
  
 0.678
rpl19
60S ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.
   
  
 0.640
psmb6
Proteasome subunit beta.
   
 
 0.577
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.