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ek1 protein (Danio rerio) - STRING interaction network
"ek1" - Ephrin type-A receptor 3 in Danio rerio
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ek1Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially efna5. Upon activation by efna5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in car [...] (981 aa)    
Predicted Functional Partners:
efna3b
Ephrin-A3b; Ephrin A3b; Belongs to the ephrin family (219 aa)
     
 
  0.933
efnb2a
Ephrin-B2a; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with ephb4 may play a central role in heart morph [...] (332 aa)
     
 
  0.916
efna2
Ephrin-A2; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the epha2 receptor may play a role in bone remodeling thro [...] (195 aa)
     
 
  0.903
efna5b
Ephrin-A5b; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the epha3 receptor [...] (187 aa)
     
 
  0.858
efnb3b
Efnb3 protein; Ephrin B3b; Belongs to the ephrin family (342 aa)
     
 
  0.849
efna3a
Ephrin-A3a; Ephrin A3a; Belongs to the ephrin family (220 aa)
     
 
  0.793
efnb1
Ephrin-B1; Ephrin B1; Belongs to the ephrin family (341 aa)
     
 
  0.785
efna2b
Ephrin-A2b; ephrin-A2; Belongs to the ephrin family (206 aa)
     
 
  0.735
efna5a
Ephrin-A5a; Ephrin A5a; Belongs to the ephrin family (237 aa)
     
 
  0.692
wfdc1
WAP four-disulfide core domain 1 (220 aa)
       
      0.692
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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