node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dclre1b | eme1 | ENSDARP00000090466 | ENSDARP00000097532 | 5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by terf2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...] | Essential meiotic structure-specific endonuclease 1. | 0.837 |
dclre1b | ercc1 | ENSDARP00000090466 | ENSDARP00000041750 | 5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by terf2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...] | Excision repair cross-complementing rodent repair deficiency, complementation group 1. | 0.809 |
dclre1b | ercc4 | ENSDARP00000090466 | ENSDARP00000018811 | 5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by terf2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...] | Excision repair cross-complementation group 4. | 0.709 |
dclre1b | exo1 | ENSDARP00000090466 | ENSDARP00000073846 | 5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by terf2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...] | Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity). | 0.742 |
dclre1b | faap24 | ENSDARP00000090466 | ENSDARP00000067890 | 5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by terf2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...] | FA core complex-associated protein 24. | 0.685 |
dclre1b | fancd2 | ENSDARP00000090466 | ENSDARP00000070083 | 5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by terf2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...] | FA complementation group D2. | 0.753 |
dclre1b | fanci | ENSDARP00000090466 | ENSDARP00000116242 | 5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by terf2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...] | FA complementation group I. | 0.728 |
dclre1b | mus81 | ENSDARP00000090466 | ENSDARP00000091555 | 5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by terf2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...] | Crossover junction endonuclease MUS81; Interacts with eme1 and eme2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. | 0.765 |
dclre1b | slx1b | ENSDARP00000090466 | ENSDARP00000132969 | 5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by terf2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...] | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | 0.842 |
dclre1b | slx4 | ENSDARP00000090466 | ENSDARP00000082010 | 5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by terf2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...] | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). | 0.731 |
eme1 | dclre1b | ENSDARP00000097532 | ENSDARP00000090466 | Essential meiotic structure-specific endonuclease 1. | 5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by terf2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres [...] | 0.837 |
eme1 | ercc1 | ENSDARP00000097532 | ENSDARP00000041750 | Essential meiotic structure-specific endonuclease 1. | Excision repair cross-complementing rodent repair deficiency, complementation group 1. | 0.936 |
eme1 | ercc4 | ENSDARP00000097532 | ENSDARP00000018811 | Essential meiotic structure-specific endonuclease 1. | Excision repair cross-complementation group 4. | 0.894 |
eme1 | exo1 | ENSDARP00000097532 | ENSDARP00000073846 | Essential meiotic structure-specific endonuclease 1. | Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity). | 0.912 |
eme1 | faap24 | ENSDARP00000097532 | ENSDARP00000067890 | Essential meiotic structure-specific endonuclease 1. | FA core complex-associated protein 24. | 0.837 |
eme1 | fancd2 | ENSDARP00000097532 | ENSDARP00000070083 | Essential meiotic structure-specific endonuclease 1. | FA complementation group D2. | 0.880 |
eme1 | fanci | ENSDARP00000097532 | ENSDARP00000116242 | Essential meiotic structure-specific endonuclease 1. | FA complementation group I. | 0.868 |
eme1 | mus81 | ENSDARP00000097532 | ENSDARP00000091555 | Essential meiotic structure-specific endonuclease 1. | Crossover junction endonuclease MUS81; Interacts with eme1 and eme2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. | 0.999 |
eme1 | slx1b | ENSDARP00000097532 | ENSDARP00000132969 | Essential meiotic structure-specific endonuclease 1. | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. | 0.978 |
eme1 | slx4 | ENSDARP00000097532 | ENSDARP00000082010 | Essential meiotic structure-specific endonuclease 1. | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). | 0.955 |