node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
capza1b | ppfibp1a | ENSDARP00000072971 | ENSDARP00000131924 | F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. | PPFIA-binding protein 1a. | 0.886 |
capza1b | tigara | ENSDARP00000072971 | ENSDARP00000097862 | F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. | Probable fructose-2,6-bisphosphatase TIGAR A; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6- bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell dea [...] | 0.833 |
capza1b | tigarb | ENSDARP00000072971 | ENSDARP00000067391 | F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. | Fructose-2,6-bisphosphatase TIGAR B; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6- bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May p [...] | 0.744 |
mpi | pfkfb1 | ENSDARP00000124229 | ENSDARP00000028010 | Mannose-6-phosphate isomerase. | 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1. | 0.912 |
mpi | pfkfb2a | ENSDARP00000124229 | ENSDARP00000093104 | Mannose-6-phosphate isomerase. | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2a. | 0.912 |
mpi | pfkfb2b | ENSDARP00000124229 | ENSDARP00000128619 | Mannose-6-phosphate isomerase. | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b. | 0.912 |
mpi | pfkfb3 | ENSDARP00000124229 | ENSDARP00000041401 | Mannose-6-phosphate isomerase. | 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3. | 0.912 |
mpi | pfkla | ENSDARP00000124229 | ENSDARP00000079719 | Mannose-6-phosphate isomerase. | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. | 0.928 |
mpi | pfkpa | ENSDARP00000124229 | ENSDARP00000029635 | Mannose-6-phosphate isomerase. | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. | 0.929 |
mpi | tigara | ENSDARP00000124229 | ENSDARP00000097862 | Mannose-6-phosphate isomerase. | Probable fructose-2,6-bisphosphatase TIGAR A; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6- bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell dea [...] | 0.907 |
mpi | tigarb | ENSDARP00000124229 | ENSDARP00000067391 | Mannose-6-phosphate isomerase. | Fructose-2,6-bisphosphatase TIGAR B; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6- bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May p [...] | 0.907 |
pfkfb1 | mpi | ENSDARP00000028010 | ENSDARP00000124229 | 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1. | Mannose-6-phosphate isomerase. | 0.912 |
pfkfb1 | pfkfb2a | ENSDARP00000028010 | ENSDARP00000093104 | 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1. | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2a. | 0.904 |
pfkfb1 | pfkfb2b | ENSDARP00000028010 | ENSDARP00000128619 | 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1. | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b. | 0.901 |
pfkfb1 | pfkfb3 | ENSDARP00000028010 | ENSDARP00000041401 | 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1. | 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3. | 0.902 |
pfkfb1 | pfkla | ENSDARP00000028010 | ENSDARP00000079719 | 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1. | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. | 0.853 |
pfkfb1 | pfkpa | ENSDARP00000028010 | ENSDARP00000029635 | 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1. | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. | 0.862 |
pfkfb1 | tigara | ENSDARP00000028010 | ENSDARP00000097862 | 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1. | Probable fructose-2,6-bisphosphatase TIGAR A; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6- bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell dea [...] | 0.941 |
pfkfb1 | tigarb | ENSDARP00000028010 | ENSDARP00000067391 | 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 1. | Fructose-2,6-bisphosphatase TIGAR B; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6- bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May p [...] | 0.941 |
pfkfb2a | mpi | ENSDARP00000093104 | ENSDARP00000124229 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2a. | Mannose-6-phosphate isomerase. | 0.912 |