STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccdc85cbCoiled-coil domain-containing protein 85C-B; May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity); Belongs to the CCDC85 family. (400 aa)    
Predicted Functional Partners:
ism2b
Isthmin-2.
      
 0.957
cyp46a1.2
Cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 2.
   
  
 0.860
cyp46a1.4
Cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 4.
      
 0.860
ccnk
Cyclin-K; Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
    
 
 0.853
dtwd1
DTW domain-containing protein 1.
      
 0.516
cyp2k6
Cytochrome P450 2K6; Metabolizes aflatoxin B1 (AFB1) to the cytotoxic derivative AFB1 exo-8,9-epoxide. Does not show activity towards lauric acid.
      
 0.482
cyp2k31
Cytochrome P450 2K6; Belongs to the cytochrome P450 family.
      
 0.480
mphosph10
U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family.
      
 0.473
nifk
MKI67 FHA domain-interacting nucleolar phosphoprotein; Plays an essential role in early embryonic development.
      
 0.473
cyp2u1
Cytochrome P450, family 2, subfamily U, polypeptide 1; Belongs to the cytochrome P450 family.
   
  
 0.469
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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