STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdx4Caudal type homeo box transcription factor 4. (270 aa)    
Predicted Functional Partners:
chic1
Novel protein similar to vertebrate cysteine-rich hydrophobic domain 1 (CHIC1).
 
    
 0.698
tbxta
T-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...]
   
 
 0.694
ogg1
8-oxoguanine DNA glycosylase.
      
 0.658
tbxtb
T-box transcription factor Tb.
   
 
 0.640
tbx16l
T-box transcription factor TBX6L; Probable transcriptional regulator involved in developmental processes.
   
 
 0.624
tbx6
T-box transcription factor TBX6; T-box transcription factor involved in the development of paraxial mesoderm.
   
 
 0.610
mex3a
RING-type domain-containing protein.
   
 
 0.595
timp2a
Tissue inhibitor of metalloproteinase 2.
      
 0.586
ace
Angiotensin-converting enzyme.
      
 0.578
wnt3a
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.
   
  
 0.574
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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