node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
bcs1l | lyrm7 | ENSDARP00000015141 | ENSDARP00000099103 | Mitochondrial chaperone BCS1; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III; Belongs to the AAA ATPase family. BCS1 subfamily. | Complex III assembly factor LYRM7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity). | 0.851 |
bcs1l | ttc19 | ENSDARP00000015141 | ENSDARP00000102293 | Mitochondrial chaperone BCS1; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III; Belongs to the AAA ATPase family. BCS1 subfamily. | Tetratricopeptide repeat protein 19, mitochondrial; Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation into the complex III and whose presence is detrimental for its catalytic activity. | 0.736 |
bcs1l | uqcrfs1 | ENSDARP00000015141 | ENSDARP00000011707 | Mitochondrial chaperone BCS1; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III; Belongs to the AAA ATPase family. BCS1 subfamily. | Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | 0.829 |
gtf2e2 | helz | ENSDARP00000020885 | ENSDARP00000044095 | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. | Probable helicase with zinc finger domain; May act as a helicase; Belongs to the DNA2/NAM7 helicase family. | 0.836 |
gtf2e2 | lyrm4 | ENSDARP00000020885 | ENSDARP00000103510 | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis. | 0.567 |
gtf2e2 | lyrm7 | ENSDARP00000020885 | ENSDARP00000099103 | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. | Complex III assembly factor LYRM7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity). | 0.832 |
gtf2e2 | lyrm9 | ENSDARP00000020885 | ENSDARP00000100356 | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. | LYR motif-containing protein 9; Belongs to the complex I LYR family. LYRM9 subfamily. | 0.807 |
gtf2e2 | uqcrfs1 | ENSDARP00000020885 | ENSDARP00000011707 | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. | Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | 0.646 |
helz | gtf2e2 | ENSDARP00000044095 | ENSDARP00000020885 | Probable helicase with zinc finger domain; May act as a helicase; Belongs to the DNA2/NAM7 helicase family. | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. | 0.836 |
helz | lyrm4 | ENSDARP00000044095 | ENSDARP00000103510 | Probable helicase with zinc finger domain; May act as a helicase; Belongs to the DNA2/NAM7 helicase family. | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis. | 0.558 |
helz | lyrm7 | ENSDARP00000044095 | ENSDARP00000099103 | Probable helicase with zinc finger domain; May act as a helicase; Belongs to the DNA2/NAM7 helicase family. | Complex III assembly factor LYRM7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity). | 0.809 |
helz | lyrm9 | ENSDARP00000044095 | ENSDARP00000100356 | Probable helicase with zinc finger domain; May act as a helicase; Belongs to the DNA2/NAM7 helicase family. | LYR motif-containing protein 9; Belongs to the complex I LYR family. LYRM9 subfamily. | 0.805 |
helz | uqcrfs1 | ENSDARP00000044095 | ENSDARP00000011707 | Probable helicase with zinc finger domain; May act as a helicase; Belongs to the DNA2/NAM7 helicase family. | Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | 0.626 |
lyrm1 | lyrm4 | ENSDARP00000039061 | ENSDARP00000103510 | LYR motif containing protein 1; Belongs to the complex I LYR family. | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis. | 0.795 |
lyrm1 | lyrm4-2 | ENSDARP00000039061 | ENSDARP00000147532 | LYR motif containing protein 1; Belongs to the complex I LYR family. | Si:ch211-152c8.4; Belongs to the complex I LYR family. | 0.919 |
lyrm1 | lyrm7 | ENSDARP00000039061 | ENSDARP00000099103 | LYR motif containing protein 1; Belongs to the complex I LYR family. | Complex III assembly factor LYRM7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity). | 0.854 |
lyrm1 | lyrm9 | ENSDARP00000039061 | ENSDARP00000100356 | LYR motif containing protein 1; Belongs to the complex I LYR family. | LYR motif-containing protein 9; Belongs to the complex I LYR family. LYRM9 subfamily. | 0.575 |
lyrm1 | sdhaf3 | ENSDARP00000039061 | ENSDARP00000052395 | LYR motif containing protein 1; Belongs to the complex I LYR family. | Succinate dehydrogenase assembly factor 3, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. | 0.928 |
lyrm4 | gtf2e2 | ENSDARP00000103510 | ENSDARP00000020885 | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis. | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. | 0.567 |
lyrm4 | helz | ENSDARP00000103510 | ENSDARP00000044095 | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis. | Probable helicase with zinc finger domain; May act as a helicase; Belongs to the DNA2/NAM7 helicase family. | 0.558 |