STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
eif2b5Eukaryotic translation initiation factor 2B, subunit 5 epsilon. (607 aa)    
Predicted Functional Partners:
eif2b1
Eukaryotic translation initiation factor 2B, subunit 1 alpha; Belongs to the eIF-2B alpha/beta/delta subunits family.
   
 0.999
eif2b3
Eukaryotic translation initiation factor 2B, subunit 3 gamma.
   
0.999
eif2b2
Eukaryotic translation initiation factor 2B, subunit 2 beta; Belongs to the eIF-2B alpha/beta/delta subunits family.
   
 0.999
eif2s2
Eukaryotic translation initiation factor 2, subunit 2 beta.
   
 0.999
eif2b4
Eukaryotic translation initiation factor 2B, subunit 4 delta; Belongs to the eIF-2B alpha/beta/delta subunits family.
   
 0.999
eif2s3
Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...]
   
 0.997
eif2s1b
Eukaryotic translation initiation factor 2, subunit 1 alpha b.
   
 0.981
eif2s1a
Eukaryotic translation initiation factor 2, subunit 1 alpha, like.
   
 0.974
eif5
Eukaryotic translation initiation factor 5.
   
 
 0.863
arih1
E3 ubiquitin-protein ligase arih1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin- protein ligase activity is activated upon binding to neddylated cullin- RING ubiquitin ligase com [...]
 
      0.823
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.