STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
znf598E3 ubiquitin-protein ligase ZNF598; E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation. Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of a subset of 40S ribosomal subunits. Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide; Belongs to the ZNF598 family. (951 aa)    
Predicted Functional Partners:
gigyf2
GRB10-interacting GYF protein 2; Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. Belongs to the GIGYF family.
   
 
 0.954
rps3
Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.
    
 
 0.895
ascc3
Activating signal cointegrator 1 complex subunit 3; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for alkbh3, enabling alkbh3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions.
    
 
 0.892
LTN1
Si:dkey-175g6.5.
   
 
 0.891
rps10
Ribosomal protein S10.
    
 
 0.870
eif4e2
Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family.
    
 
 0.861
ascc2
Activating signal cointegrator 1 complex subunit 2.
   
 
 0.856
rack1
Guanine nucleotide-binding protein subunit beta-2-like 1; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
    
 
 0.835
znhit1
Zinc finger, HIT-type-containing 1.
      
 0.831
rps2
Ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family.
    
 
 0.821
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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