STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
intuProtein inturned; Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity); Belongs to the inturned family. (926 aa)    
Predicted Functional Partners:
wdpcp
WD repeat-containing planar cell polarity effector.
   
 
 0.942
cplane2
Ciliogenesis and planar polarity effector 2; Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity). Belongs to the small GTPase superfamily. Rab family.
    
 
 0.902
fuz
Fuzzy planar cell polarity protein.
   
 
 0.849
cdc27
Cell division cycle 27.
   
 
 0.848
cdc16
Cell division cycle 16 homolog (S. cerevisiae).
   
 
 0.844
cdc23
CDC23 (Cell division cycle 23, yeast, homolog).
   
 
 0.836
bub3
BUB3 mitotic checkpoint protein.
   
 
 0.832
anapc5
Anaphase-promoting complex subunit 5.
    
 
 0.825
ube2c
Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.825
nek2
NIMA (Never in mitosis gene a)-related kinase 2.
   
 
 0.824
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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