node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENKD1 | tmem129 | ENSDARP00000121477 | ENSDARP00000101988 | Si:ch211-220d9.3. | E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Belongs to the TMEM129 family. | 0.438 |
RNF5 | derl1 | ENSDARP00000099944 | ENSDARP00000036613 | Ring finger protein 5. | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.730 |
RNF5 | rnf185 | ENSDARP00000099944 | ENSDARP00000046780 | Ring finger protein 5. | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and [...] | 0.531 |
RNF5 | sel1l | ENSDARP00000099944 | ENSDARP00000007196 | Ring finger protein 5. | SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. | 0.697 |
RNF5 | tmem129 | ENSDARP00000099944 | ENSDARP00000101988 | Ring finger protein 5. | E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Belongs to the TMEM129 family. | 0.410 |
derl1 | RNF5 | ENSDARP00000036613 | ENSDARP00000099944 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | Ring finger protein 5. | 0.730 |
derl1 | rnf139 | ENSDARP00000036613 | ENSDARP00000053621 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | Ring finger protein 139. | 0.574 |
derl1 | rnf185 | ENSDARP00000036613 | ENSDARP00000046780 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and [...] | 0.769 |
derl1 | sel1l | ENSDARP00000036613 | ENSDARP00000007196 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. | 0.994 |
derl1 | tmem129 | ENSDARP00000036613 | ENSDARP00000101988 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Belongs to the TMEM129 family. | 0.549 |
pex6 | tmem129 | ENSDARP00000095384 | ENSDARP00000101988 | Peroxisomal biogenesis factor 6. | E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Belongs to the TMEM129 family. | 0.622 |
pskh1 | tmem129 | ENSDARP00000073709 | ENSDARP00000101988 | Serine/threonine-protein kinase H1 homolog; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Belongs to the TMEM129 family. | 0.553 |
rnf139 | derl1 | ENSDARP00000053621 | ENSDARP00000036613 | Ring finger protein 139. | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.574 |
rnf139 | sel1l | ENSDARP00000053621 | ENSDARP00000007196 | Ring finger protein 139. | SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. | 0.560 |
rnf139 | tmem129 | ENSDARP00000053621 | ENSDARP00000101988 | Ring finger protein 139. | E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Belongs to the TMEM129 family. | 0.433 |
rnf185 | RNF5 | ENSDARP00000046780 | ENSDARP00000099944 | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and [...] | Ring finger protein 5. | 0.531 |
rnf185 | derl1 | ENSDARP00000046780 | ENSDARP00000036613 | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and [...] | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.769 |
rnf185 | sel1l | ENSDARP00000046780 | ENSDARP00000007196 | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and [...] | SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. | 0.724 |
rnf185 | tmem129 | ENSDARP00000046780 | ENSDARP00000101988 | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and [...] | E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Belongs to the TMEM129 family. | 0.410 |
sel1l | RNF5 | ENSDARP00000007196 | ENSDARP00000099944 | SEL1L adaptor subunit of ERAD E3 ubiquitin ligase. | Ring finger protein 5. | 0.697 |