STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dtx4aDeltex 4, E3 ubiquitin ligase a. (704 aa)    
Predicted Functional Partners:
notch1a
Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]
    
 0.912
notch2
Notch receptor 2.
    
 0.870
notch3
Notch receptor 3.
    
 0.831
notch1b
Notch receptor 1b.
    
 0.771
itchb
E3 ubiquitin-protein ligase.
    
 0.676
her8a
Hairy-related 8a.
    
 
 0.675
maml1
Mastermind-like transcriptional coactivator 1.
      
 0.656
arl6ip4
ADP-ribosylation factor-like protein 6-interacting protein 4; May be involved in modulating alternative pre-mRNA splicing. Belongs to the ARL6IP4 family.
      
 0.648
wwp2
E3 ubiquitin-protein ligase.
    
 
 0.608
mib2
Mindbomb E3 ubiquitin protein ligase 2.
    
 
 0.608
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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