STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
map2k4aMitogen-activated protein kinase kinase 4A; Belongs to the protein kinase superfamily. (404 aa)    
Predicted Functional Partners:
mapk9
Mitogen-activated protein kinase.
   
0.989
map3k7
Mitogen-activated protein kinase kinase kinase 7.
   
0.987
map3k1
Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase.
   
0.978
mapk8b
Mitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock.
   
0.977
mapk10
Mitogen-activated protein kinase.
   
0.976
mapk8a
Mitogen-activated protein kinase.
   
0.974
map2k7
Mitogen-activated protein kinase kinase 7.
   
0.935
crkl
V-crk sarcoma virus CT10 oncogene homolog (Avian)-like.
   
 
 0.920
arrb2b
Arrestin, beta 2b.
    
 0.919
arrb2a
Arrestin, beta 2a.
    
 0.919
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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