STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
smoc2SPARC-related modular calcium-binding 2. (437 aa)    
Predicted Functional Partners:
wdr27
WD repeat domain 27.
   
  
 0.673
fam204a
Family with sequence similarity 204 member A.
      
 0.628
dact2
Dapper homolog 2; Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Positive regulator of the Wnt signaling pathway which acts downstream of wnt1 indicative for non- canonical Wnt signaling. Also negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors. Required for convergent extension movements in gastrulation.
      
 0.626
sipa1l2
Signal-induced proliferation-associated 1-like 2.
   
  
 0.620
phf10
PHD finger protein 10; Involved in transcription activity regulation by chromatin remodeling in the context of the neural progenitors-specific chromatin remodeling complex (npBAF complex). May play a role in the proliferation of neural progenitors (By similarity).
      
 0.599
tnmd
Tenomodulin.
      
 0.597
acsf2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial; Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation; Belongs to the ATP-dependent AMP-binding enzyme family.
      
 0.586
FRMD1
Zgc:172136 protein.
      
 0.583
lcorl
Ligand-dependent nuclear receptor corepressor-like.
   
  
 0.576
ndnf
Neuron-derived neurotrophic factor.
      
 0.565
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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