node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aspm | cenpj | ENSDARP00000135909 | ENSDARP00000155698 | Abnormal spindle microtubule assembly. | Centromere protein J. | 0.982 |
aspm | cep135 | ENSDARP00000135909 | ENSDARP00000035272 | Abnormal spindle microtubule assembly. | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity). Belongs to the CEP135/TSGA10 family. | 0.864 |
aspm | cep63 | ENSDARP00000135909 | ENSDARP00000073875 | Abnormal spindle microtubule assembly. | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). | 0.855 |
aspm | pcnt | ENSDARP00000135909 | ENSDARP00000125930 | Abnormal spindle microtubule assembly. | Pericentrin. | 0.826 |
aspm | plk1 | ENSDARP00000135909 | ENSDARP00000075786 | Abnormal spindle microtubule assembly. | Serine/threonine-protein kinase PLK. | 0.647 |
aspm | plk4 | ENSDARP00000135909 | ENSDARP00000043865 | Abnormal spindle microtubule assembly. | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenes [...] | 0.852 |
aspm | sass6 | ENSDARP00000135909 | ENSDARP00000075634 | Abnormal spindle microtubule assembly. | Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole- dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity). | 0.604 |
aspm | stil | ENSDARP00000135909 | ENSDARP00000037419 | Abnormal spindle microtubule assembly. | SCL-interrupting locus protein homolog; Plays an essential role in early embryonic development. Plays an important role in the regulation of centriole duplication (By similarity). | 0.970 |
aspm | wdr62 | ENSDARP00000135909 | ENSDARP00000098255 | Abnormal spindle microtubule assembly. | WD repeat domain 62. | 0.986 |
ccdc14 | cep135 | ENSDARP00000130704 | ENSDARP00000035272 | Coiled-coil domain-containing 14. | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity). Belongs to the CEP135/TSGA10 family. | 0.565 |
ccdc14 | cep63 | ENSDARP00000130704 | ENSDARP00000073875 | Coiled-coil domain-containing 14. | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). | 0.927 |
ccdc14 | plk4 | ENSDARP00000130704 | ENSDARP00000043865 | Coiled-coil domain-containing 14. | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenes [...] | 0.738 |
ccdc14 | sass6 | ENSDARP00000130704 | ENSDARP00000075634 | Coiled-coil domain-containing 14. | Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole- dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity). | 0.642 |
ccdc14 | stil | ENSDARP00000130704 | ENSDARP00000037419 | Coiled-coil domain-containing 14. | SCL-interrupting locus protein homolog; Plays an essential role in early embryonic development. Plays an important role in the regulation of centriole duplication (By similarity). | 0.481 |
ccdc14 | wdr62 | ENSDARP00000130704 | ENSDARP00000098255 | Coiled-coil domain-containing 14. | WD repeat domain 62. | 0.561 |
cenpj | aspm | ENSDARP00000155698 | ENSDARP00000135909 | Centromere protein J. | Abnormal spindle microtubule assembly. | 0.982 |
cenpj | cep135 | ENSDARP00000155698 | ENSDARP00000035272 | Centromere protein J. | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity). Belongs to the CEP135/TSGA10 family. | 0.982 |
cenpj | cep63 | ENSDARP00000155698 | ENSDARP00000073875 | Centromere protein J. | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). | 0.957 |
cenpj | pcnt | ENSDARP00000155698 | ENSDARP00000125930 | Centromere protein J. | Pericentrin. | 0.960 |
cenpj | plk1 | ENSDARP00000155698 | ENSDARP00000075786 | Centromere protein J. | Serine/threonine-protein kinase PLK. | 0.912 |