node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dpysl3 | nrp1a | ENSDARP00000065096 | ENSDARP00000140900 | Dihydropyrimidinase-related protein 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | 0.761 |
dpysl3 | plxna2 | ENSDARP00000065096 | ENSDARP00000152904 | Dihydropyrimidinase-related protein 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | Plexin A2. | 0.666 |
dpysl3 | plxna3 | ENSDARP00000065096 | ENSDARP00000043999 | Dihydropyrimidinase-related protein 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. | 0.592 |
dpysl3 | sema3d | ENSDARP00000065096 | ENSDARP00000091966 | Dihydropyrimidinase-related protein 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | Semaphorin-3D; May play a role in the guidance of several axon pathways. | 0.746 |
nrp1a | dpysl3 | ENSDARP00000140900 | ENSDARP00000065096 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Dihydropyrimidinase-related protein 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | 0.761 |
nrp1a | nrp2b | ENSDARP00000140900 | ENSDARP00000056102 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Neuropilin; Belongs to the neuropilin family. | 0.472 |
nrp1a | plxna2 | ENSDARP00000140900 | ENSDARP00000152904 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Plexin A2. | 0.962 |
nrp1a | plxna3 | ENSDARP00000140900 | ENSDARP00000043999 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. | 0.947 |
nrp1a | plxnd1 | ENSDARP00000140900 | ENSDARP00000112069 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Plexin D1. | 0.926 |
nrp1a | sema3d | ENSDARP00000140900 | ENSDARP00000091966 | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | Semaphorin-3D; May play a role in the guidance of several axon pathways. | 0.956 |
nrp1b | plxna2 | ENSDARP00000089037 | ENSDARP00000152904 | Neuropilin 1b. | Plexin A2. | 0.719 |
nrp1b | plxna3 | ENSDARP00000089037 | ENSDARP00000043999 | Neuropilin 1b. | Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. | 0.759 |
nrp1b | plxnd1 | ENSDARP00000089037 | ENSDARP00000112069 | Neuropilin 1b. | Plexin D1. | 0.807 |
nrp1b | sema3d | ENSDARP00000089037 | ENSDARP00000091966 | Neuropilin 1b. | Semaphorin-3D; May play a role in the guidance of several axon pathways. | 0.798 |
nrp2a | plxna3 | ENSDARP00000125533 | ENSDARP00000043999 | Neuropilin; Belongs to the neuropilin family. | Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. | 0.809 |
nrp2a | sema3d | ENSDARP00000125533 | ENSDARP00000091966 | Neuropilin; Belongs to the neuropilin family. | Semaphorin-3D; May play a role in the guidance of several axon pathways. | 0.805 |
nrp2b | nrp1a | ENSDARP00000056102 | ENSDARP00000140900 | Neuropilin; Belongs to the neuropilin family. | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. | 0.472 |
nrp2b | plxna2 | ENSDARP00000056102 | ENSDARP00000152904 | Neuropilin; Belongs to the neuropilin family. | Plexin A2. | 0.454 |
nrp2b | plxna3 | ENSDARP00000056102 | ENSDARP00000043999 | Neuropilin; Belongs to the neuropilin family. | Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. | 0.674 |
nrp2b | plxnd1 | ENSDARP00000056102 | ENSDARP00000112069 | Neuropilin; Belongs to the neuropilin family. | Plexin D1. | 0.480 |