STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dthd1Death domain-containing 1. (740 aa)    
Predicted Functional Partners:
rd3
Retinal degeneration 3, GUCY2D regulator.
      
 0.672
sh3bp4
SH3-domain-binding protein 4.
      
 0.669
sh3bp4a
SH3 domain-binding protein 4-A; Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity).
      
 0.669
prdm13
PR domain-containing 13.
      
 0.645
TULP1
Tubby-related protein 1-like.
      
 0.615
aipl1
Aryl hydrocarbon receptor-interacting protein-like 1.
      
 0.597
pde6ha
Phosphodiesterase 6H, cGMP-specific, cone, gamma, paralog a.
      
 0.583
unc5c
Unc-5 netrin receptor C.
      
 0.559
UNC5C
Si:ch73-72b7.1.
      
 0.554
pde6c
Phosphodiesterase.
      
 0.552
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.