STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dph22-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). (498 aa)    
Predicted Functional Partners:
dph3
Diphthamide biosynthesis 3.
   
 0.996
dph5
Diphthamide biosynthesis 5.
   
 0.996
dph1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; May be required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). Belongs to the DPH1/DPH2 family. DPH1 subfamily.
   
0.995
dph7
Diphthamide biosynthesis 7.
      
 0.990
dph6
Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (By similarity). Belongs to the Diphthine--ammonia ligase family.
   
  
 0.941
eef2l2
Eukaryotic translation elongation factor 2,-like 2.
    
 0.900
eef2a.2
Eukaryotic translation elongation factor 2a, tandem duplicate 2.
    
 0.900
eef2a.1
Eukaryotic translation elongation factor 2a, tandem duplicate 1.
    
 0.899
eef2b
Eukaryotic translation elongation factor 2, like.
    
 
 0.850
dnajc24
DnaJ (Hsp40) homolog, subfamily C, member 24.
   
 
 0.833
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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