hsf2bp protein (Danio rerio) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

hsf2bp

Heat shock transcription factor 2-binding protein. (365 aa)

Predicted Functional Partners:

brca2

0.918

spata22

0.863

lrrc42

0.860

syce2

0.858

tmem183a

0.851

ankrd10a

0.833

rpa3

0.779

gpr137c

0.768

hfm1

0.766

m1ap

0.756

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ankrd10a	hsf2bp	ENSDARP00000053925	ENSDARP00000114662	Ankyrin repeat domain 10a.	Heat shock transcription factor 2-binding protein.	0.833
brca2	hsf2bp	ENSDARP00000099674	ENSDARP00000114662	BRCA2 DNA repair-associated.	Heat shock transcription factor 2-binding protein.	0.918
brca2	rpa3	ENSDARP00000099674	ENSDARP00000015592	BRCA2 DNA repair-associated.	Replication protein A3.	0.774
gpr137c	hsf2bp	ENSDARP00000066603	ENSDARP00000114662	G protein-coupled receptor 137ba.	Heat shock transcription factor 2-binding protein.	0.768
gpr137c	lrrc42	ENSDARP00000066603	ENSDARP00000045055	G protein-coupled receptor 137ba.	Leucine-rich repeat-containing protein 42; Belongs to the LRRC42 family.	0.860
gpr137c	m1ap	ENSDARP00000066603	ENSDARP00000136086	G protein-coupled receptor 137ba.	Meiosis 1-associated protein.	0.767
gpr137c	spata22	ENSDARP00000066603	ENSDARP00000136480	G protein-coupled receptor 137ba.	Spermatogenesis-associated 22.	0.649
gpr137c	syce2	ENSDARP00000066603	ENSDARP00000137317	G protein-coupled receptor 137ba.	Synaptonemal complex central element protein 2.	0.747
hfm1	hsf2bp	ENSDARP00000137345	ENSDARP00000114662	Helicase for meiosis 1.	Heat shock transcription factor 2-binding protein.	0.766
hfm1	spata22	ENSDARP00000137345	ENSDARP00000136480	Helicase for meiosis 1.	Spermatogenesis-associated 22.	0.756
hsf2bp	ankrd10a	ENSDARP00000114662	ENSDARP00000053925	Heat shock transcription factor 2-binding protein.	Ankyrin repeat domain 10a.	0.833
hsf2bp	brca2	ENSDARP00000114662	ENSDARP00000099674	Heat shock transcription factor 2-binding protein.	BRCA2 DNA repair-associated.	0.918
hsf2bp	gpr137c	ENSDARP00000114662	ENSDARP00000066603	Heat shock transcription factor 2-binding protein.	G protein-coupled receptor 137ba.	0.768
hsf2bp	hfm1	ENSDARP00000114662	ENSDARP00000137345	Heat shock transcription factor 2-binding protein.	Helicase for meiosis 1.	0.766
hsf2bp	lrrc42	ENSDARP00000114662	ENSDARP00000045055	Heat shock transcription factor 2-binding protein.	Leucine-rich repeat-containing protein 42; Belongs to the LRRC42 family.	0.860
hsf2bp	m1ap	ENSDARP00000114662	ENSDARP00000136086	Heat shock transcription factor 2-binding protein.	Meiosis 1-associated protein.	0.756
hsf2bp	rpa3	ENSDARP00000114662	ENSDARP00000015592	Heat shock transcription factor 2-binding protein.	Replication protein A3.	0.779
hsf2bp	spata22	ENSDARP00000114662	ENSDARP00000136480	Heat shock transcription factor 2-binding protein.	Spermatogenesis-associated 22.	0.863
hsf2bp	syce2	ENSDARP00000114662	ENSDARP00000137317	Heat shock transcription factor 2-binding protein.	Synaptonemal complex central element protein 2.	0.858
hsf2bp	tmem183a	ENSDARP00000114662	ENSDARP00000065995	Heat shock transcription factor 2-binding protein.	Transmembrane protein 183A.	0.851

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.817

expected number of edges:

117

PPI enrichment p-value:

1

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098869

Cellular oxidant detoxification

8 of 33

2.57

7.61

3.11e-16

GO:0045454

Cell redox homeostasis

4 of 13

2.67

3.74

9.32e-08

GO:0006979

Response to oxidative stress

5 of 73

2.02

3.02

3.00e-07

GO:0034599

Cellular response to oxidative stress

4 of 33

2.27

2.88

2.06e-06

GO:0010035

Response to inorganic substance

4 of 86

1.85

2.05

3.91e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016209

Antioxidant activity

8 of 40

2.49

7.32

5.66e-16

GO:0004601

Peroxidase activity

4 of 17

2.56

3.39

3.73e-07

GO:0004784

Superoxide dismutase activity

3 of 6

2.88

2.89

5.14e-06

GO:0051920

Peroxiredoxin activity

3 of 7

2.82

2.87

5.24e-06

GO:0016491

Oxidoreductase activity

8 of 616

1.3

1.74

3.73e-07

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000123

Histone acetyltransferase complex

2 of 24

2.11

0.71

0.0476

GO:0005739

Mitochondrion

5 of 583

1.12

0.7

0.0150

GO:0070013

Intracellular organelle lumen

4 of 585

1.02

0.52

0.0476

GO:0043231

Intracellular membrane-bounded organelle

9 of 4332

0.5

0.31

0.0476

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9327

Detoxification of Reactive Oxygen Species, and Peroxiredoxin, AhpC-type

7 of 21

2.71

7.18

9.63e-15

CL:9329

Cell redox homeostasis, and Protein repair

3 of 11

2.62

2.45

2.85e-05

CL:9356

Superoxide dismutase activity, and DJ-1/PfpI family

2 of 5

2.79

1.42

0.0026

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04146

Peroxisome

5 of 112

1.84

2.62

8.63e-07

map00480

Glutathione metabolism

4 of 86

1.85

2.19

1.59e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3299685

Detoxification of Reactive Oxygen Species

5 of 26

2.47

4.33

3.27e-09

MAP-9711123

Cellular response to chemical stress

7 of 117

1.96

3.96

3.01e-10

MAP-8953897

Cellular responses to stimuli

7 of 401

1.43

1.99

4.45e-07

MAP-2262752

Cellular responses to stress

7 of 401

1.43

1.99

4.45e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0560

Oxidoreductase

3 of 156

1.47

0.74

0.0286

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10417

C-terminal domain of 1-Cys peroxiredoxin

2 of 2

3.19

1.39

0.0031

PF02777

Iron/manganese superoxide dismutases, C-terminal domain

2 of 2

3.19

1.39

0.0031

PF00578

AhpC/TSA family

2 of 9

2.53

1.1

0.0096

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024706

Peroxiredoxin, AhpC-type

3 of 3

3.19

2.66

1.50e-05

IPR000866

Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant

3 of 8

2.76

2.29

6.18e-05

IPR045020

1-Cys peroxiredoxin

2 of 2

3.19

1.54

0.0017

IPR036314

Manganese/iron superoxide dismutase, C-terminal domain superfamily

2 of 2

3.19

1.54

0.0017

IPR019832

Manganese/iron superoxide dismutase, C-terminal

2 of 2

3.19

1.54

0.0017

(more ...)

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