STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sox12Transcription factor SOX. (355 aa)    
Predicted Functional Partners:
ZNF512B
Si:dkey-256k13.2.
    
 
 0.652
ctnnb1
Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...]
    
 0.544
scrt1b
Scratch family zinc finger 1b.
   
  
 0.496
sox4a
Transcription factor SOX.
  
  
0.492
ddx43
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43; Belongs to the DEAD box helicase family.
    
 
 0.486
scrt1a
Scratch family zinc finger 1a.
   
  
 0.485
sox6
SRY-box transcription factor 6.
   
0.478
foxp1a
Forkhead box P1a.
   
 
 0.471
tlx2
T cell leukemia homeobox 2.
    
 
 0.470
lhx4
LIM homeobox 4.
   
 
 0.466
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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