STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fxnFrataxin. (200 aa)    
Predicted Functional Partners:
nfs1
NFS1 nitrogen fixation 1 (S. cerevisiae).
   
 0.999
ISCU
Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.
    
 0.998
fech
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
   
 0.997
lyrm4
LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.
    
 
 0.995
scly
Selenocysteine lyase.
   
 0.990
lyrm4-2
Si:ch211-152c8.4; Belongs to the complex I LYR family.
    
 0.988
slc25a37
Mitoferrin-1; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme.
   
 
 0.953
nfu1
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae).
   
  
 0.949
abcb7
ATP-binding cassette, sub-family B (MDR/TAP), member 7.
   
  
 0.948
iba57
Putative transferase CAF17 homolog, mitochondrial; Required for normal heme biosynthesis.
   
  
 0.945
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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