node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC100334178 | ube2l3a | ENSDARP00000109107 | ENSDARP00000152691 | Uncharacterized protein. | Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family. | 0.569 |
LOC100334178 | ube2l3b | ENSDARP00000109107 | ENSDARP00000116310 | Uncharacterized protein. | Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family. | 0.775 |
UBA6 | trip12 | ENSDARP00000102515 | ENSDARP00000082000 | Si:dkey-82j4.2. | E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spr [...] | 0.597 |
UBA6 | uba1 | ENSDARP00000102515 | ENSDARP00000054690 | Si:dkey-82j4.2. | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | 0.912 |
UBA6 | uba7 | ENSDARP00000102515 | ENSDARP00000128383 | Si:dkey-82j4.2. | Ubiquitin-like modifier-activating enzyme 7; Belongs to the ubiquitin-activating E1 family. | 0.911 |
UBA6 | ube2l3a | ENSDARP00000102515 | ENSDARP00000152691 | Si:dkey-82j4.2. | Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family. | 0.784 |
UBA6 | ube2l3b | ENSDARP00000102515 | ENSDARP00000116310 | Si:dkey-82j4.2. | Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family. | 0.784 |
UBA6 | ube2v1 | ENSDARP00000102515 | ENSDARP00000067116 | Si:dkey-82j4.2. | Ubiquitin-conjugating enzyme E2 variant 1. | 0.769 |
arih1 | ube2l3a | ENSDARP00000006476 | ENSDARP00000152691 | E3 ubiquitin-protein ligase arih1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin- protein ligase activity is activated upon binding to neddylated cullin- RING ubiquitin ligase com [...] | Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family. | 0.848 |
arih1 | ube2l3b | ENSDARP00000006476 | ENSDARP00000116310 | E3 ubiquitin-protein ligase arih1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin- protein ligase activity is activated upon binding to neddylated cullin- RING ubiquitin ligase com [...] | Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family. | 0.849 |
prkn | ube2l3a | ENSDARP00000141580 | ENSDARP00000152691 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family. | 0.920 |
prkn | ube2l3b | ENSDARP00000141580 | ENSDARP00000116310 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family. | 0.958 |
prkn | ube2v1 | ENSDARP00000141580 | ENSDARP00000067116 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | Ubiquitin-conjugating enzyme E2 variant 1. | 0.669 |
trip12 | UBA6 | ENSDARP00000082000 | ENSDARP00000102515 | E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spr [...] | Si:dkey-82j4.2. | 0.597 |
trip12 | uba1 | ENSDARP00000082000 | ENSDARP00000054690 | E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spr [...] | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | 0.669 |
trip12 | uba7 | ENSDARP00000082000 | ENSDARP00000128383 | E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spr [...] | Ubiquitin-like modifier-activating enzyme 7; Belongs to the ubiquitin-activating E1 family. | 0.680 |
trip12 | ube2l3a | ENSDARP00000082000 | ENSDARP00000152691 | E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spr [...] | Ubiquitin-conjugating enzyme E2L 3a; Belongs to the ubiquitin-conjugating enzyme family. | 0.911 |
trip12 | ube2l3b | ENSDARP00000082000 | ENSDARP00000116310 | E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spr [...] | Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family. | 0.907 |
uba1 | UBA6 | ENSDARP00000054690 | ENSDARP00000102515 | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | Si:dkey-82j4.2. | 0.912 |
uba1 | trip12 | ENSDARP00000054690 | ENSDARP00000082000 | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spr [...] | 0.669 |