STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pou2f1bPOU domain protein. (676 aa)    
Predicted Functional Partners:
ep300b
E1A-binding protein p300 b.
   
 0.818
znf143a
Zinc finger protein 143a.
    
  0.804
jun
Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.
    
 0.654
zeb1a
Zinc finger E-box-binding homeobox 1a.
   
 
 0.649
hdac1
Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
   
 0.598
gata3
Transcription factor GATA-3.
   
 0.587
sp1
Sp1 transcription factor.
    
 0.578
vox
Ventral homeobox.
    
 
 0.578
snapc4
Small nuclear RNA-activating complex, polypeptide 4.
    
  0.569
pou2af1
Uncharacterized protein.
    
 
 0.567
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.