node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cdh1 | cdh18a | ENSDARP00000136579 | ENSDARP00000089931 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Cadherin 18, type 2a. | 0.540 |
cdh1 | cdh2 | ENSDARP00000136579 | ENSDARP00000003949 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. | 0.929 |
cdh1 | cdh28 | ENSDARP00000136579 | ENSDARP00000138222 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Cadherin 28. | 0.546 |
cdh1 | cdh4 | ENSDARP00000136579 | ENSDARP00000134356 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Cadherin 4, type 1, R-cadherin (retinal); Cadherins are calcium-dependent cell adhesion proteins. | 0.607 |
cdh1 | cdh6 | ENSDARP00000136579 | ENSDARP00000117877 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Cadherin 6; Cadherins are calcium-dependent cell adhesion proteins. | 0.617 |
cdh1 | ctnna1 | ENSDARP00000136579 | ENSDARP00000132933 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Catenin (cadherin-associated protein), alpha 1. | 0.859 |
cdh1 | ctnna2 | ENSDARP00000136579 | ENSDARP00000092080 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system; Belongs to the vinculin/alpha-catenin family. | 0.775 |
cdh1 | ctnnb1 | ENSDARP00000136579 | ENSDARP00000139205 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.999 |
cdh1 | jupa | ENSDARP00000136579 | ENSDARP00000026915 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | Junction plakoglobin a. | 0.991 |
cdh18a | cdh1 | ENSDARP00000089931 | ENSDARP00000136579 | Cadherin 18, type 2a. | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | 0.540 |
cdh18a | cdh2 | ENSDARP00000089931 | ENSDARP00000003949 | Cadherin 18, type 2a. | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. | 0.657 |
cdh18a | cdh28 | ENSDARP00000089931 | ENSDARP00000138222 | Cadherin 18, type 2a. | Cadherin 28. | 0.540 |
cdh18a | cdh4 | ENSDARP00000089931 | ENSDARP00000134356 | Cadherin 18, type 2a. | Cadherin 4, type 1, R-cadherin (retinal); Cadherins are calcium-dependent cell adhesion proteins. | 0.669 |
cdh18a | cdh6 | ENSDARP00000089931 | ENSDARP00000117877 | Cadherin 18, type 2a. | Cadherin 6; Cadherins are calcium-dependent cell adhesion proteins. | 0.810 |
cdh18a | ctnna1 | ENSDARP00000089931 | ENSDARP00000132933 | Cadherin 18, type 2a. | Catenin (cadherin-associated protein), alpha 1. | 0.610 |
cdh18a | ctnna2 | ENSDARP00000089931 | ENSDARP00000092080 | Cadherin 18, type 2a. | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system; Belongs to the vinculin/alpha-catenin family. | 0.610 |
cdh18a | ctnnb1 | ENSDARP00000089931 | ENSDARP00000139205 | Cadherin 18, type 2a. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.643 |
cdh18a | jupa | ENSDARP00000089931 | ENSDARP00000026915 | Cadherin 18, type 2a. | Junction plakoglobin a. | 0.626 |
cdh2 | cdh1 | ENSDARP00000003949 | ENSDARP00000136579 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | 0.929 |
cdh2 | cdh18a | ENSDARP00000003949 | ENSDARP00000089931 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. | Cadherin 18, type 2a. | 0.657 |