node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
amt | bhmt | ENSDARP00000081585 | ENSDARP00000040421 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | 0.650 |
amt | mthfd1a | ENSDARP00000081585 | ENSDARP00000150792 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | C-1-tetrahydrofolate synthase, cytoplasmic isoform X2. | 0.950 |
amt | mthfd1b | ENSDARP00000081585 | ENSDARP00000020770 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 1b. | 0.958 |
amt | mthfd2 | ENSDARP00000081585 | ENSDARP00000132963 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Mthfd2 protein. | 0.991 |
amt | mthfd2l | ENSDARP00000081585 | ENSDARP00000070824 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 2-like. | 0.993 |
amt | mthfr | ENSDARP00000081585 | ENSDARP00000121987 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.988 |
amt | mtr | ENSDARP00000081585 | ENSDARP00000139035 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.618 |
amt | shmt1 | ENSDARP00000081585 | ENSDARP00000069223 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.987 |
amt | shmt2 | ENSDARP00000081585 | ENSDARP00000132340 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine hydroxymethyltransferase 2 (mitochondrial). | 0.986 |
amt | tyms | ENSDARP00000081585 | ENSDARP00000047068 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Thymidylate synthetase. | 0.982 |
bhmt | amt | ENSDARP00000040421 | ENSDARP00000081585 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.650 |
bhmt | mthfd1a | ENSDARP00000040421 | ENSDARP00000150792 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | C-1-tetrahydrofolate synthase, cytoplasmic isoform X2. | 0.580 |
bhmt | mthfd1b | ENSDARP00000040421 | ENSDARP00000020770 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 1b. | 0.676 |
bhmt | mthfd2 | ENSDARP00000040421 | ENSDARP00000132963 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Mthfd2 protein. | 0.805 |
bhmt | mthfd2l | ENSDARP00000040421 | ENSDARP00000070824 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 2-like. | 0.763 |
bhmt | mthfr | ENSDARP00000040421 | ENSDARP00000121987 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.981 |
bhmt | mtr | ENSDARP00000040421 | ENSDARP00000139035 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.623 |
bhmt | shmt1 | ENSDARP00000040421 | ENSDARP00000069223 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.764 |
bhmt | shmt2 | ENSDARP00000040421 | ENSDARP00000132340 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Serine hydroxymethyltransferase 2 (mitochondrial). | 0.720 |
bhmt | tyms | ENSDARP00000040421 | ENSDARP00000047068 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). | Thymidylate synthetase. | 0.561 |