STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gpr176G protein-coupled receptor 176. (545 aa)    
Predicted Functional Partners:
adgrg2a
Adhesion G protein-coupled receptor G2a; Belongs to the G-protein coupled receptor 2 family.
      
 0.831
adgrd1
Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.
      
 0.807
adgrg6
Adhesion G-protein coupled receptor G6; G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Plays also a role in inner ear development.
   
  
 0.736
he1.2
Metalloendopeptidase.
      
 0.720
vstm5
IG domain-containing protein.
      
 0.694
adgra2
Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...]
      
 0.645
gpr20
G protein-coupled receptor 20; Belongs to the G-protein coupled receptor 1 family.
     
 0.549
gpr25
G protein-coupled receptor 25; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.546
GNAZ
G protein subunit alpha z.
    
 
 0.521
gpr75
G protein-coupled receptor 75.
      
 0.514
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.