node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
adgra2 | fzd10 | ENSDARP00000103078 | ENSDARP00000089291 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.478 |
adgra2 | fzd4 | ENSDARP00000103078 | ENSDARP00000139144 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.831 |
adgra2 | lrp5 | ENSDARP00000103078 | ENSDARP00000108864 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] | Low density lipoprotein receptor-related protein 5. | 0.838 |
adgra2 | ndp | ENSDARP00000103078 | ENSDARP00000125102 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] | Norrin cystine knot growth factor NDP. | 0.903 |
adgra2 | tspan12 | ENSDARP00000103078 | ENSDARP00000048002 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] | Tetraspanin. | 0.759 |
adgra2 | wnt7aa | ENSDARP00000103078 | ENSDARP00000065888 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.852 |
adgra2 | wnt7ba | ENSDARP00000103078 | ENSDARP00000011793 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.837 |
faua | faub | ENSDARP00000141629 | ENSDARP00000064110 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | 0.994 |
faua | ndp | ENSDARP00000141629 | ENSDARP00000125102 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | Norrin cystine knot growth factor NDP. | 0.742 |
faub | faua | ENSDARP00000064110 | ENSDARP00000141629 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | 0.994 |
faub | ndp | ENSDARP00000064110 | ENSDARP00000125102 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | Norrin cystine knot growth factor NDP. | 0.742 |
fzd10 | adgra2 | ENSDARP00000089291 | ENSDARP00000103078 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] | 0.478 |
fzd10 | lrp5 | ENSDARP00000089291 | ENSDARP00000108864 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | Low density lipoprotein receptor-related protein 5. | 0.976 |
fzd10 | ndp | ENSDARP00000089291 | ENSDARP00000125102 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | Norrin cystine knot growth factor NDP. | 0.933 |
fzd10 | wnt7aa | ENSDARP00000089291 | ENSDARP00000065888 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.887 |
fzd10 | wnt7ba | ENSDARP00000089291 | ENSDARP00000011793 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.908 |
fzd4 | adgra2 | ENSDARP00000139144 | ENSDARP00000103078 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with reck to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: Required for normal central nervous system (CNS) vascularization where it functions cell-autonomously in the tip cells of sprouting vessels. Has a role in development of dorsal root ganglia. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 co [...] | 0.831 |
fzd4 | lrp5 | ENSDARP00000139144 | ENSDARP00000108864 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Low density lipoprotein receptor-related protein 5. | 0.986 |
fzd4 | ndp | ENSDARP00000139144 | ENSDARP00000125102 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Norrin cystine knot growth factor NDP. | 0.999 |
fzd4 | tspan12 | ENSDARP00000139144 | ENSDARP00000048002 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Tetraspanin. | 0.974 |