akap12a protein (Danio rerio) - STRING interaction network

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

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Score

akap12a

A kinase (PRKA) anchor protein 12a. (3023 aa)

Predicted Functional Partners:

gna14a

0.865

urgcp

0.863

appbp2

0.838

apba2b

0.745

gna14

0.740

fetub

0.694

pnp5a

0.668

rps26l

0.660

trim35-3

0.649

man2b2

0.647

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
akap12a	apba2b	ENSDARP00000127555	ENSDARP00000142680	A kinase (PRKA) anchor protein 12a.	Amyloid beta (A4) precursor protein-binding, family A, member 2b.	0.745
akap12a	appbp2	ENSDARP00000127555	ENSDARP00000027941	A kinase (PRKA) anchor protein 12a.	Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.	0.838
akap12a	fetub	ENSDARP00000127555	ENSDARP00000070561	A kinase (PRKA) anchor protein 12a.	Fetuin B.	0.694
akap12a	gna14	ENSDARP00000127555	ENSDARP00000123766	A kinase (PRKA) anchor protein 12a.	Guanine nucleotide-binding protein (G protein), alpha 14.	0.740
akap12a	gna14a	ENSDARP00000127555	ENSDARP00000122726	A kinase (PRKA) anchor protein 12a.	Guanine nucleotide-binding protein (G protein), alpha 14a.	0.865
akap12a	man2b2	ENSDARP00000127555	ENSDARP00000099510	A kinase (PRKA) anchor protein 12a.	Alpha-mannosidase.	0.647
akap12a	pnp5a	ENSDARP00000127555	ENSDARP00000093456	A kinase (PRKA) anchor protein 12a.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.668
akap12a	rps26l	ENSDARP00000127555	ENSDARP00000111782	A kinase (PRKA) anchor protein 12a.	40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family.	0.660
akap12a	trim35-3	ENSDARP00000127555	ENSDARP00000068566	A kinase (PRKA) anchor protein 12a.	Tripartite motif-containing 35-3.	0.649
akap12a	urgcp	ENSDARP00000127555	ENSDARP00000126031	A kinase (PRKA) anchor protein 12a.	Upregulator of cell proliferation.	0.863
apba2b	akap12a	ENSDARP00000142680	ENSDARP00000127555	Amyloid beta (A4) precursor protein-binding, family A, member 2b.	A kinase (PRKA) anchor protein 12a.	0.745
apba2b	appbp2	ENSDARP00000142680	ENSDARP00000027941	Amyloid beta (A4) precursor protein-binding, family A, member 2b.	Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.	0.678
apba2b	fetub	ENSDARP00000142680	ENSDARP00000070561	Amyloid beta (A4) precursor protein-binding, family A, member 2b.	Fetuin B.	0.480
apba2b	gna14	ENSDARP00000142680	ENSDARP00000123766	Amyloid beta (A4) precursor protein-binding, family A, member 2b.	Guanine nucleotide-binding protein (G protein), alpha 14.	0.540
apba2b	gna14a	ENSDARP00000142680	ENSDARP00000122726	Amyloid beta (A4) precursor protein-binding, family A, member 2b.	Guanine nucleotide-binding protein (G protein), alpha 14a.	0.744
apba2b	man2b2	ENSDARP00000142680	ENSDARP00000099510	Amyloid beta (A4) precursor protein-binding, family A, member 2b.	Alpha-mannosidase.	0.404
apba2b	pnp5a	ENSDARP00000142680	ENSDARP00000093456	Amyloid beta (A4) precursor protein-binding, family A, member 2b.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.453
apba2b	rps26l	ENSDARP00000142680	ENSDARP00000111782	Amyloid beta (A4) precursor protein-binding, family A, member 2b.	40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family.	0.408
apba2b	trim35-3	ENSDARP00000142680	ENSDARP00000068566	Amyloid beta (A4) precursor protein-binding, family A, member 2b.	Tripartite motif-containing 35-3.	0.407
apba2b	urgcp	ENSDARP00000142680	ENSDARP00000126031	Amyloid beta (A4) precursor protein-binding, family A, member 2b.	Upregulator of cell proliferation.	0.742

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Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.876

expected number of edges:

11

PPI enrichment p-value:

2.4e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045454

Cell redox homeostasis

3 of 20

2.33

1.29

0.0041

GO:0016259

Selenocysteine metabolic process

2 of 2

3.15

1.07

0.0121

GO:0006777

Mo-molybdopterin cofactor biosynthetic process

2 of 8

2.55

0.8

0.0347

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004791

Thioredoxin-disulfide reductase activity

3 of 9

2.68

2.33

5.04e-05

GO:0016783

Sulfurtransferase activity

3 of 10

2.63

2.32

5.04e-05

GO:0015035

Protein-disulfide reductase activity

4 of 37

2.19

2.27

3.53e-05

GO:0070279

Vitamin B6 binding

3 of 53

1.9

1.33

0.0023

GO:0050660

Flavin adenine dinucleotide binding

3 of 82

1.72

1.09

0.0060

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17367

Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor, and Redox-active center

4 of 13

2.64

3.19

1.05e-06

CL:17369

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, and Glutathione oxidoreductase activity

2 of 5

2.75

1.21

0.0063

CL:19473

Mitochondrial iron-sulfur cluster biogenesis, and Selenocysteine metabolic process

2 of 8

2.55

1.07

0.0112

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00450

Selenocompound metabolism

6 of 17

2.7

6.38

4.48e-13

map04122

Sulfur relay system

2 of 10

2.45

1.38

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2408522

Selenoamino acid metabolism

5 of 22

2.51

4.18

7.96e-09

MAP-3299685

Detoxification of Reactive Oxygen Species

4 of 35

2.21

2.63

6.11e-06

MAP-71291

Metabolism of amino acids and derivatives

6 of 247

1.54

1.95

6.11e-06

MAP-5263617

Metabolism of ingested MeSeO2H into MeSeH

2 of 2

3.15

1.69

0.00090

MAP-499943

Interconversion of nucleotide di- and triphosphates

3 of 40

2.03

1.55

0.00090

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0676

Redox-active center

4 of 15

2.58

3.56

1.77e-07

KW-0663

Pyridoxal phosphate

3 of 38

2.05

1.69

0.00047

KW-0520

NAD

3 of 60

1.85

1.44

0.0012

KW-0274

FAD

3 of 63

1.83

1.43

0.0012

KW-0560

Oxidoreductase

3 of 245

1.24

0.64

0.0342

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

3 of 5

2.93

2.49

2.86e-05

PF00890

FAD binding domain

3 of 11

2.59

2.18

9.28e-05

PF00070

Pyridine nucleotide-disulphide oxidoreductase

2 of 4

2.85

1.3

0.0044

PF01212

Beta-eliminating lyase

2 of 7

2.61

1.15

0.0080

PF00266

Aminotransferase class-V

2 of 8

2.55

1.15

0.0080

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