node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aep1 | hephl1a | ENSDARP00000057100 | ENSDARP00000128173 | Aerolysin-like protein; Pore-forming protein which might play a role in host defense. Exists as an antiparallel dimer in solution. Can also assemble into an octameric pore-like structure spanning the cell membrane. Oligomerization may be triggered by binding of the jacalin-type lectin domain to high-mannose cell-surface proteoglycans, and also requires a low pH environment. In vitro, shows high binding affinity for S.cerevisiae mannan and human HIV virus glycoprotein gp120. | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | 0.714 |
aep1 | tcnbb | ENSDARP00000057100 | ENSDARP00000114787 | Aerolysin-like protein; Pore-forming protein which might play a role in host defense. Exists as an antiparallel dimer in solution. Can also assemble into an octameric pore-like structure spanning the cell membrane. Oligomerization may be triggered by binding of the jacalin-type lectin domain to high-mannose cell-surface proteoglycans, and also requires a low pH environment. In vitro, shows high binding affinity for S.cerevisiae mannan and human HIV virus glycoprotein gp120. | Transcobalamin beta b. | 0.836 |
ankrd37 | hephl1a | ENSDARP00000094013 | ENSDARP00000128173 | Ankyrin repeat domain 37. | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | 0.676 |
edil3a | hephl1a | ENSDARP00000135442 | ENSDARP00000128173 | EGF-like repeats and discoidin I-like domains 3a. | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | 0.616 |
edil3b | hephl1a | ENSDARP00000080662 | ENSDARP00000128173 | EGF-like repeats and discoidin I-like domains 3b. | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | 0.576 |
hephl1a | aep1 | ENSDARP00000128173 | ENSDARP00000057100 | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | Aerolysin-like protein; Pore-forming protein which might play a role in host defense. Exists as an antiparallel dimer in solution. Can also assemble into an octameric pore-like structure spanning the cell membrane. Oligomerization may be triggered by binding of the jacalin-type lectin domain to high-mannose cell-surface proteoglycans, and also requires a low pH environment. In vitro, shows high binding affinity for S.cerevisiae mannan and human HIV virus glycoprotein gp120. | 0.714 |
hephl1a | ankrd37 | ENSDARP00000128173 | ENSDARP00000094013 | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | Ankyrin repeat domain 37. | 0.676 |
hephl1a | edil3a | ENSDARP00000128173 | ENSDARP00000135442 | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | EGF-like repeats and discoidin I-like domains 3a. | 0.616 |
hephl1a | edil3b | ENSDARP00000128173 | ENSDARP00000080662 | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | EGF-like repeats and discoidin I-like domains 3b. | 0.576 |
hephl1a | lrtm1 | ENSDARP00000128173 | ENSDARP00000132529 | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | Leucine-rich repeats and transmembrane domains 1. | 0.807 |
hephl1a | med17 | ENSDARP00000128173 | ENSDARP00000023604 | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.594 |
hephl1a | smco4 | ENSDARP00000128173 | ENSDARP00000129760 | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | Single-pass membrane protein with coiled-coil domains 4. | 0.830 |
hephl1a | sqor | ENSDARP00000128173 | ENSDARP00000117779 | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | Sulfide quinone oxidoreductase. | 0.585 |
hephl1a | tcnbb | ENSDARP00000128173 | ENSDARP00000114787 | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | Transcobalamin beta b. | 0.838 |
hephl1a | vstm5 | ENSDARP00000128173 | ENSDARP00000100883 | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | IG domain-containing protein. | 0.863 |
lrtm1 | hephl1a | ENSDARP00000132529 | ENSDARP00000128173 | Leucine-rich repeats and transmembrane domains 1. | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | 0.807 |
med17 | hephl1a | ENSDARP00000023604 | ENSDARP00000128173 | Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | 0.594 |
med17 | smco4 | ENSDARP00000023604 | ENSDARP00000129760 | Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | Single-pass membrane protein with coiled-coil domains 4. | 0.697 |
med17 | vstm5 | ENSDARP00000023604 | ENSDARP00000100883 | Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | IG domain-containing protein. | 0.886 |
smco4 | hephl1a | ENSDARP00000129760 | ENSDARP00000128173 | Single-pass membrane protein with coiled-coil domains 4. | Hephaestin-like 1a; Belongs to the multicopper oxidase family. | 0.830 |