STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
htr45-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (454 aa)    
Predicted Functional Partners:
gnal
Guanine nucleotide-binding protein G(olf) subunit alpha.
    
 0.810
Gnal2
Uncharacterized protein.
    
 0.810
gna15.2
Guanine nucleotide-binding protein (G protein), alpha 15 (Gq class), tandem duplicate 3.
    
 
 0.769
mis12
MIS12 kinetochore complex component.
      
 0.670
ercc6l
DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
      
 0.646
ube2d1b
Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.
      
 0.644
polr2eb
Polymerase (RNA) II (DNA directed) polypeptide E, b.
      
 0.562
sfswap
Splicing factor SWAP.
      
 0.558
htr3b
5-hydroxytryptamine (serotonin) receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
      
 0.551
akirin2
Akirin 2.
      
 0.542
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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