STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ideNovel protein similar to H.sapiens IDE, insulin-degrading enzyme (IDE, zgc:162603); Belongs to the peptidase M16 family. (998 aa)    
Predicted Functional Partners:
ins
Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.982
mmel1
Membrane metallo-endopeptidase-like 1.
      
 0.925
rps27a
Ribosomal protein S27a.
   
 0.922
appa
Amyloid beta (A4) precursor protein a.
    
 
 0.907
igf2b
Insulin-like growth factor 2b.
    
 
 0.869
appb
Amyloid beta (A4) precursor protein b.
    
 
 0.861
nppa
Natriuretic peptide A.
    
 
 0.826
tgfa
Transforming growth factor, alpha.
    
 
 0.815
nppb
Natriuretic peptide B.
    
 
 0.814
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
   
   0.812
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.