node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PRKAR2B | gli3 | ENSDARP00000154977 | ENSDARP00000058991 | Si:ch211-272n13.7. | GLI family zinc finger 3. | 0.522 |
PRKAR2B | prkacaa | ENSDARP00000154977 | ENSDARP00000135348 | Si:ch211-272n13.7. | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. | 0.968 |
PRKAR2B | prkar1aa | ENSDARP00000154977 | ENSDARP00000121293 | Si:ch211-272n13.7. | Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) a. | 0.914 |
PRKAR2B | prkar1ab | ENSDARP00000154977 | ENSDARP00000138282 | Si:ch211-272n13.7. | Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b. | 0.905 |
PRKAR2B | prkar1b | ENSDARP00000154977 | ENSDARP00000140440 | Si:ch211-272n13.7. | Protein kinase, cAMP-dependent, regulatory, type I, beta. | 0.919 |
PRKAR2B | sufu | ENSDARP00000154977 | ENSDARP00000133214 | Si:ch211-272n13.7. | Suppressor of fused homolog. | 0.499 |
ctnnb1 | gli2a | ENSDARP00000139205 | ENSDARP00000010693 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | GLI family zinc finger 2a. | 0.703 |
ctnnb1 | gli3 | ENSDARP00000139205 | ENSDARP00000058991 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | GLI family zinc finger 3. | 0.788 |
ctnnb1 | gsk3ba | ENSDARP00000139205 | ENSDARP00000027785 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. | 0.999 |
ctnnb1 | prkacaa | ENSDARP00000139205 | ENSDARP00000135348 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. | 0.962 |
ctnnb1 | smo | ENSDARP00000139205 | ENSDARP00000013486 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.758 |
ctnnb1 | sufu | ENSDARP00000139205 | ENSDARP00000133214 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Suppressor of fused homolog. | 0.521 |
gli2a | ctnnb1 | ENSDARP00000010693 | ENSDARP00000139205 | GLI family zinc finger 2a. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.703 |
gli2a | gli3 | ENSDARP00000010693 | ENSDARP00000058991 | GLI family zinc finger 2a. | GLI family zinc finger 3. | 0.590 |
gli2a | gsk3ba | ENSDARP00000010693 | ENSDARP00000027785 | GLI family zinc finger 2a. | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. | 0.599 |
gli2a | prkacaa | ENSDARP00000010693 | ENSDARP00000135348 | GLI family zinc finger 2a. | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. | 0.972 |
gli2a | smo | ENSDARP00000010693 | ENSDARP00000013486 | GLI family zinc finger 2a. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.990 |
gli2a | sufu | ENSDARP00000010693 | ENSDARP00000133214 | GLI family zinc finger 2a. | Suppressor of fused homolog. | 0.997 |
gli3 | PRKAR2B | ENSDARP00000058991 | ENSDARP00000154977 | GLI family zinc finger 3. | Si:ch211-272n13.7. | 0.522 |
gli3 | ctnnb1 | ENSDARP00000058991 | ENSDARP00000139205 | GLI family zinc finger 3. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.788 |