si:dkey-16p6.1-14 protein (Danio rerio) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

si:dkey-16p6.1-14

Si:dkey-16p6.1. (1234 aa)

Predicted Functional Partners:

zgc:171776

0.480

adgrl2b.1

0.480

zgc:171781

0.480

F1R0Z3_DANRE

0.480

LOC110438301

0.480

F1R862_DANRE

0.480

A8HAI9_DANRE

0.480

adgrl2b.1-2

0.480

A8HAI7_DANRE

0.480

ADGRL3

0.480

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A8HAI7_DANRE	si:dkey-16p6.1-14	ENSDARP00000108507	ENSDARP00000135862	Si:ch211-12h2.6.	Si:dkey-16p6.1.	0.480
A8HAI9_DANRE	si:dkey-16p6.1-14	ENSDARP00000103528	ENSDARP00000135862	Si:ch211-12h2.8.	Si:dkey-16p6.1.	0.480
ADGRL3	si:dkey-16p6.1-14	ENSDARP00000109937	ENSDARP00000135862	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	Si:dkey-16p6.1.	0.480
F1R0Z3_DANRE	si:dkey-16p6.1-14	ENSDARP00000093527	ENSDARP00000135862	Si:dkey-179j5.5.	Si:dkey-16p6.1.	0.480
F1R862_DANRE	si:dkey-16p6.1-14	ENSDARP00000096079	ENSDARP00000135862	Si:ch211-226h8.4.	Si:dkey-16p6.1.	0.480
LOC110438301	si:dkey-16p6.1-14	ENSDARP00000096076	ENSDARP00000135862	Si:ch211-226h8.6.	Si:dkey-16p6.1.	0.480
adgrl2b.1	si:dkey-16p6.1-14	ENSDARP00000081195	ENSDARP00000135862	Adhesion G protein-coupled receptor L2b, tandem duplicate 1.	Si:dkey-16p6.1.	0.480
adgrl2b.1-2	si:dkey-16p6.1-14	ENSDARP00000104202	ENSDARP00000135862	Si:ch1073-186i23.1; Belongs to the G-protein coupled receptor 2 family.	Si:dkey-16p6.1.	0.480
si:dkey-16p6.1-14	A8HAI7_DANRE	ENSDARP00000135862	ENSDARP00000108507	Si:dkey-16p6.1.	Si:ch211-12h2.6.	0.480
si:dkey-16p6.1-14	A8HAI9_DANRE	ENSDARP00000135862	ENSDARP00000103528	Si:dkey-16p6.1.	Si:ch211-12h2.8.	0.480
si:dkey-16p6.1-14	ADGRL3	ENSDARP00000135862	ENSDARP00000109937	Si:dkey-16p6.1.	Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.	0.480
si:dkey-16p6.1-14	F1R0Z3_DANRE	ENSDARP00000135862	ENSDARP00000093527	Si:dkey-16p6.1.	Si:dkey-179j5.5.	0.480
si:dkey-16p6.1-14	F1R862_DANRE	ENSDARP00000135862	ENSDARP00000096079	Si:dkey-16p6.1.	Si:ch211-226h8.4.	0.480
si:dkey-16p6.1-14	LOC110438301	ENSDARP00000135862	ENSDARP00000096076	Si:dkey-16p6.1.	Si:ch211-226h8.6.	0.480
si:dkey-16p6.1-14	adgrl2b.1	ENSDARP00000135862	ENSDARP00000081195	Si:dkey-16p6.1.	Adhesion G protein-coupled receptor L2b, tandem duplicate 1.	0.480
si:dkey-16p6.1-14	adgrl2b.1-2	ENSDARP00000135862	ENSDARP00000104202	Si:dkey-16p6.1.	Si:ch1073-186i23.1; Belongs to the G-protein coupled receptor 2 family.	0.480
si:dkey-16p6.1-14	zgc:171776	ENSDARP00000135862	ENSDARP00000043066	Si:dkey-16p6.1.	Zgc:171776.	0.480
si:dkey-16p6.1-14	zgc:171781	ENSDARP00000135862	ENSDARP00000089834	Si:dkey-16p6.1.	Zgc:171781.	0.480
zgc:171776	si:dkey-16p6.1-14	ENSDARP00000043066	ENSDARP00000135862	Zgc:171776.	Si:dkey-16p6.1.	0.480
zgc:171781	si:dkey-16p6.1-14	ENSDARP00000089834	ENSDARP00000135862	Zgc:171781.	Si:dkey-16p6.1.	0.480

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

17

PPI enrichment p-value:

3.4e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098609

Cell-cell adhesion

5 of 435

1.54

1.27

0.0013

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045294

Alpha-catenin binding

2 of 10

2.78

0.97

0.0174

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0014704

Intercalated disc

2 of 11

2.74

1.28

0.0048

GO:0005911

Cell-cell junction

4 of 317

1.58

1.15

0.0032

GO:0016342

Catenin complex

2 of 30

2.31

0.98

0.0154

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:37965

Cadherin-like superfamily, and Plakophilin/Delta catenin

5 of 97

2.2

3.1

5.32e-07

CL:38071

Mixed, incl. Limb expression 1, and Retina layer formation

3 of 11

2.92

2.95

3.94e-06

CL:6049

RHOU GTPase cycle, and Unconventional class IX myosin

3 of 14

2.81

2.83

6.30e-06

CL:37972

Cadherin-like superfamily, and Plakophilin/Delta catenin

4 of 85

2.16

2.61

5.75e-06

CL:38074

Limb expression 1, and Retina layer formation

2 of 5

3.09

1.87

0.00042

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04392

Hippo signaling pathway - multiple species

3 of 102

1.95

1.51

0.00098

map04520

Adherens junction

3 of 115

1.9

1.49

0.00098

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9013026

RHOB GTPase cycle

3 of 71

2.11

1.35

0.0027

MAP-8980692

RHOA GTPase cycle

3 of 178

1.71

0.86

0.0199

MAP-5218920

VEGFR2 mediated vascular permeability

2 of 35

2.24

0.79

0.0347

MAP-418990

Adherens junctions interactions

2 of 40

2.18

0.79

0.0347

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005911

Cell-cell junction

4 of 224

1.74

1.42

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0518

Myosin

2 of 56

2.04

0.7

0.0499

KW-0106

Calcium

3 of 368

1.39

0.62

0.0499

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046987

Unconventional class IX myosin

3 of 4

3.36

2.87

6.62e-06

IPR036023

Class IX myosin, motor domain

2 of 2

3.48

1.49

0.0021

IPR013284

Beta-catenin

2 of 3

3.31

1.47

0.0023

IPR020894

Cadherin conserved site

3 of 107

1.93

1.04

0.0100

IPR015919

Cadherin-like superfamily

3 of 122

1.87

0.99

0.0118

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00112

Cadherin repeats.

3 of 118

1.89

1.14

0.0057

SM00314

Ras association (RalGDS/AF-6) domain

2 of 30

2.31

0.94

0.0187

SM00185

Armadillo/beta-catenin-like repeats

2 of 32

2.28

0.94

0.0187

SM00242

Myosin. Large ATPases.

2 of 38

2.2

0.93

0.0187

SM00282

Laminin G domain

2 of 50

2.09

0.91

0.0199

(more ...)

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