STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
scn1laaSodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1955 aa)    
Predicted Functional Partners:
scn1ba
Voltage-gated sodium channel beta 1 subunit splice variant D.
   
 0.989
scn2b
Voltage-gated sodium channel beta 2 subunit splice variant D.
   
 0.932
scn1bb
Sodium channel, voltage-gated, type I, beta b.
   
 0.921
scn3b
Sodium channel, voltage-gated, type III, beta.
   
 0.890
stxbp1a
Syntaxin-binding protein 1a; Belongs to the STXBP/unc-18/SEC1 family.
   
  
 0.868
pcdh19
Protocadherin 19.
      
 0.838
gabrg2
Gamma-aminobutyric acid (GABA) A receptor, gamma 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.835
kcna1a
Potassium voltage-gated channel, shaker-related subfamily, member 1a; Belongs to the potassium channel family.
    
 
 0.826
kcnt1
Potassium channel, subfamily T, member 1.
   
 
 0.823
kcnq3
Potassium voltage-gated channel, KQT-like subfamily, member 3; Belongs to the potassium channel family.
    
 
 0.811
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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