STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
srsf11Serine and arginine-rich-splicing factor 11. (461 aa)    
Predicted Functional Partners:
rnps1-2
RNA-binding protein with serine-rich domain 1; Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Putative component of the spliceosome which enhances the formation of the ATP-dependent A complex of the spliceosome. May participate in mRNA 3'-end cleavage. Also mediates increase of mRNA a [...]
   
 0.963
srsf7b
Serine and arginine-rich-splicing factor 7b.
   
 0.933
srsf9
Serine and arginine-rich-splicing factor 9.
   
 0.925
rnps1
RNA binding protein S1, serine-rich domain.
   
 
 0.922
srsf3b
Serine and arginine-rich-splicing factor 3b.
   
 0.888
srsf1b
Serine/arginine-rich splicing factor 1B; May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Belongs to the splicing factor SR family.
   
 0.858
slu7
Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
     
 0.857
srsf5b
Serine and arginine-rich-splicing factor 5b.
   
 0.854
cdc40
Cell division cycle 40 homolog (S. cerevisiae).
     
 0.833
pabpn1
Poly(A)-binding protein, nuclear 1.
   
 0.825
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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