STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lrrtm4l2Leucine-rich repeat transmembrane neuronal 4-like 2. (579 aa)    
Predicted Functional Partners:
vstm4b
V-set and transmembrane domain-containing 4b.
    
 
 0.954
lrrtm1
Leucine-rich repeat transmembrane neuronal 1.
  
 
0.578
nrxn1a
Neurexin-1a-beta; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in formation or maintenance of synaptic junctions; Belongs to the neurexin family.
    
  0.559
NRXN2
Neurexin 2.
    
  0.559
lrrtm4l1
Leucine-rich repeat transmembrane neuronal 4-like 1.
  
 
0.553
fmodb
Fibromodulin b.
  
  
 
0.521
fmoda
Fibromodulin a.
  
  
 
0.518
nrros
Transforming growth factor beta activator LRRC33; Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF- beta-1 activation mediated by lrrc33/nrros is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighbo [...]
  
     0.518
LOC100534875
Uncharacterized protein.
  
     0.515
si:dkey-1h4.4
Si:dkey-1h4.4.
  
     0.514
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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