htr2b protein (Danio rerio) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

htr2b

5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (443 aa)

Predicted Functional Partners:

gnaq

0.967

gna11b

0.923

tph1a

0.787

tph1b

0.743

gna14a

0.731

slc6a4b

0.694

gna15.4

0.685

gna15.1

0.685

gna14

0.685

slc6a4a

0.652

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
gna11b	gna14	ENSDARP00000044410	ENSDARP00000123766	Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class).	Guanine nucleotide-binding protein (G protein), alpha 14.	0.546
gna11b	gna14a	ENSDARP00000044410	ENSDARP00000122726	Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class).	Guanine nucleotide-binding protein (G protein), alpha 14a.	0.545
gna11b	gna15.1	ENSDARP00000044410	ENSDARP00000123739	Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class).	Guanine nucleotide-binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1.	0.570
gna11b	gna15.4	ENSDARP00000044410	ENSDARP00000121165	Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class).	Guanine nucleotide-binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	0.579
gna11b	gnaq	ENSDARP00000044410	ENSDARP00000020119	Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class).	Guanine nucleotide-binding protein (G protein), q polypeptide.	0.901
gna11b	htr2b	ENSDARP00000044410	ENSDARP00000147603	Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class).	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled.	0.923
gna14	gna11b	ENSDARP00000123766	ENSDARP00000044410	Guanine nucleotide-binding protein (G protein), alpha 14.	Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class).	0.546
gna14	gna14a	ENSDARP00000123766	ENSDARP00000122726	Guanine nucleotide-binding protein (G protein), alpha 14.	Guanine nucleotide-binding protein (G protein), alpha 14a.	0.546
gna14	gna15.1	ENSDARP00000123766	ENSDARP00000123739	Guanine nucleotide-binding protein (G protein), alpha 14.	Guanine nucleotide-binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1.	0.557
gna14	gna15.4	ENSDARP00000123766	ENSDARP00000121165	Guanine nucleotide-binding protein (G protein), alpha 14.	Guanine nucleotide-binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	0.558
gna14	gnaq	ENSDARP00000123766	ENSDARP00000020119	Guanine nucleotide-binding protein (G protein), alpha 14.	Guanine nucleotide-binding protein (G protein), q polypeptide.	0.552
gna14	htr2b	ENSDARP00000123766	ENSDARP00000147603	Guanine nucleotide-binding protein (G protein), alpha 14.	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled.	0.685
gna14a	gna11b	ENSDARP00000122726	ENSDARP00000044410	Guanine nucleotide-binding protein (G protein), alpha 14a.	Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class).	0.545
gna14a	gna14	ENSDARP00000122726	ENSDARP00000123766	Guanine nucleotide-binding protein (G protein), alpha 14a.	Guanine nucleotide-binding protein (G protein), alpha 14.	0.546
gna14a	gna15.1	ENSDARP00000122726	ENSDARP00000123739	Guanine nucleotide-binding protein (G protein), alpha 14a.	Guanine nucleotide-binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1.	0.571
gna14a	gna15.4	ENSDARP00000122726	ENSDARP00000121165	Guanine nucleotide-binding protein (G protein), alpha 14a.	Guanine nucleotide-binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	0.580
gna14a	gnaq	ENSDARP00000122726	ENSDARP00000020119	Guanine nucleotide-binding protein (G protein), alpha 14a.	Guanine nucleotide-binding protein (G protein), q polypeptide.	0.546
gna14a	htr2b	ENSDARP00000122726	ENSDARP00000147603	Guanine nucleotide-binding protein (G protein), alpha 14a.	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled.	0.731
gna15.1	gna11b	ENSDARP00000123739	ENSDARP00000044410	Guanine nucleotide-binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1.	Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class).	0.570
gna15.1	gna14	ENSDARP00000123739	ENSDARP00000123766	Guanine nucleotide-binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1.	Guanine nucleotide-binding protein (G protein), alpha 14.	0.557

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.861

expected number of edges:

13

PPI enrichment p-value:

0.00999

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070925

Organelle assembly

6 of 126

2.03

3.43

2.58e-08

GO:0051231

Spindle elongation

3 of 3

3.35

8.90e-07

GO:0090307

Mitotic spindle assembly

3 of 10

2.83

2.87

5.25e-06

GO:0007018

Microtubule-based movement

5 of 157

1.85

2.52

2.00e-06

GO:0022607

Cellular component assembly

7 of 390

1.6

2.47

1.13e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003777

Microtubule motor activity

5 of 101

2.04

2.87

8.42e-07

GO:0008017

Microtubule binding

5 of 126

1.95

2.75

9.70e-07

GO:0140657

ATP-dependent activity

6 of 597

1.35

1.55

2.02e-05

GO:0005515

Protein binding

6 of 1282

1.02

0.84

0.0015

GO:0035639

Purine ribonucleoside triphosphate binding

6 of 1740

0.89

0.62

0.0074

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015630

Microtubule cytoskeleton

9 of 291

1.84

4.43

1.90e-13

GO:0005874

Microtubule

6 of 131

2.01

3.75

2.67e-09

GO:0005815

Microtubule organizing center

4 of 91

1.99

2.53

4.47e-06

GO:0005929

Cilium

3 of 96

1.84

1.59

0.00052

GO:0036064

Ciliary basal body

2 of 28

2.2

1.3

0.0035

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4249

Mixed, incl. Small GTPase superfamily, ARF type, and Spindle pole body-associated protein Vik1/Cik1, microtubule binding domain

5 of 12

2.97

5.41

9.02e-11

CL:4252

Mixed, incl. Ciliary membrane, and Long-chain fatty acid metabolic process

4 of 5

3.25

5.02

7.03e-10

CL:4227

Mixed, incl. Kelch, and Kinesin motor domain, conserved site

6 of 51

2.42

4.98

9.02e-11

CL:4549

Kinesin motor domain, and Microtubule minus-end

4 of 27

2.52

3.62

1.15e-07

CL:4554

Mixed, incl. Chromosome passenger complex, and POLO box domain

2 of 6

2.87

1.77

0.00060

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983189

Kinesins

4 of 63

2.15

2.43

1.41e-05

MAP-6811434

COPI-dependent Golgi-to-ER retrograde traffic

4 of 87

2.01

2.24

2.45e-05

MAP-8856688

Golgi-to-ER retrograde transport

4 of 96

1.97

2.21

2.45e-05

MAP-983231

Factors involved in megakaryocyte development and platelet production

4 of 99

1.96

2.2

2.45e-05

MAP-6811442

Intra-Golgi and retrograde Golgi-to-ER traffic

4 of 130

1.84

2.0

4.66e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034464

BBSome

3 of 3

3.35

3.3

1.08e-06

GOCC:0015630

Microtubule cytoskeleton

5 of 202

1.74

2.2

7.26e-06

GOCC:0043226

Organelle

9 of 5058

0.6

0.45

0.0037

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0493

Microtubule

5 of 61

2.26

3.87

1.22e-08

KW-0505

Motor protein

5 of 85

2.12

3.54

2.98e-08

KW-0547

Nucleotide-binding

6 of 670

1.3

1.51

1.29e-05

KW-0067

ATP-binding

5 of 594

1.27

1.26

0.00019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001752

Kinesin motor domain

5 of 66

2.23

3.23

3.01e-07

IPR036961

Kinesin motor domain superfamily

5 of 81

2.14

3.1

4.02e-07

IPR019821

Kinesin motor domain, conserved site

4 of 44

2.31

2.71

5.29e-06

IPR047149

Kinesin-like protein KIF11-like

2 of 2

3.35

1.67

0.0010

IPR027640

Kinesin-like protein

3 of 61

2.04

1.38

0.0021

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00129

Kinesin motor, catalytic domain. ATPase.

4 of 61

2.17

2.63

5.36e-06

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