STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kdf1aKeratinocyte differentiation factor 1a. (383 aa)    
Predicted Functional Partners:
ripk4
Receptor-interacting serine-threonine kinase 4.
   
 
 0.816
grhl3
Grainyhead-like transcription factor 3.
   
  
 0.567
irf6
Interferon regulatory factor 6.
   
  
 0.527
fam83hb
Protein FAM83H; May play a role in keratin cytoskeleton disassembly. Belongs to the FAM83 family.
  
  
 0.449
chuk
Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
    
 
 0.428
rab25a
Novel protein similar to vertebrate RAB25, member RAS oncogene family (RAB25).
   
  
 0.426
rab25b
RAB25, member RAS oncogene family b.
   
  
 0.426
ovol1a
Ovo-like zinc finger 1a.
   
  
 0.413
rif1
Replication timing regulatory factor 1.
    
 
 0.411
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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