ENSDARP00000152258 protein (Danio rerio) - STRING interaction network

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ENSDARP00000152258

NACHT domain-containing protein. (870 aa)

Predicted Functional Partners:

ikbkb

0.517

chuk

0.505

traf6

0.418

usp14

0.416

traf2a

0.400

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSDARP00000152258	chuk	ENSDARP00000152258	ENSDARP00000013115	NACHT domain-containing protein.	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	0.505
ENSDARP00000152258	ikbkb	ENSDARP00000152258	ENSDARP00000117685	NACHT domain-containing protein.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.517
ENSDARP00000152258	traf2a	ENSDARP00000152258	ENSDARP00000043465	NACHT domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.400
ENSDARP00000152258	traf6	ENSDARP00000152258	ENSDARP00000036715	NACHT domain-containing protein.	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.	0.418
ENSDARP00000152258	usp14	ENSDARP00000152258	ENSDARP00000037906	NACHT domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.416
chuk	ENSDARP00000152258	ENSDARP00000013115	ENSDARP00000152258	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	NACHT domain-containing protein.	0.505
chuk	ikbkb	ENSDARP00000013115	ENSDARP00000117685	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.939
chuk	traf2a	ENSDARP00000013115	ENSDARP00000043465	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.793
chuk	traf6	ENSDARP00000013115	ENSDARP00000036715	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.	0.995
chuk	usp14	ENSDARP00000013115	ENSDARP00000037906	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Ubiquitin carboxyl-terminal hydrolase.	0.429
ikbkb	ENSDARP00000152258	ENSDARP00000117685	ENSDARP00000152258	Inhibitor of nuclear factor kappa B kinase subunit beta.	NACHT domain-containing protein.	0.517
ikbkb	chuk	ENSDARP00000117685	ENSDARP00000013115	Inhibitor of nuclear factor kappa B kinase subunit beta.	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	0.939
ikbkb	traf2a	ENSDARP00000117685	ENSDARP00000043465	Inhibitor of nuclear factor kappa B kinase subunit beta.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.722
ikbkb	traf6	ENSDARP00000117685	ENSDARP00000036715	Inhibitor of nuclear factor kappa B kinase subunit beta.	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.	0.869
ikbkb	usp14	ENSDARP00000117685	ENSDARP00000037906	Inhibitor of nuclear factor kappa B kinase subunit beta.	Ubiquitin carboxyl-terminal hydrolase.	0.442
traf2a	ENSDARP00000152258	ENSDARP00000043465	ENSDARP00000152258	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	NACHT domain-containing protein.	0.400
traf2a	chuk	ENSDARP00000043465	ENSDARP00000013115	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	0.793
traf2a	ikbkb	ENSDARP00000043465	ENSDARP00000117685	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.722
traf2a	traf6	ENSDARP00000043465	ENSDARP00000036715	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.	0.930
traf6	ENSDARP00000152258	ENSDARP00000036715	ENSDARP00000152258	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.	NACHT domain-containing protein.	0.418

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