STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
frmd8FERM domain-containing protein 8; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway. (471 aa)    
Predicted Functional Partners:
znrd2
Zinc ribbon domain-containing 2.
      
 0.844
slc25a45
Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.815
itgb1bp1
Integrin beta-1-binding protein 1.
    
 
 0.814
kcnk7
Potassium channel, subfamily K, member 7; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
      
 0.802
fam89b
Family with sequence similarity 89 member B.
      
 0.768
ENSDARP00000152658
FERM domain-containing protein.
    
 
 0.724
pbld
Phenazine biosynthesis-like protein domain-containing.
      
 0.718
cdc42ep2
CDC42 effector protein (Rho GTPase-binding) 2.
      
 0.711
ppm1na
Protein phosphatase, Mg2+/Mn2+-dependent, 1Na (putative).
   
  
 0.675
ppm1nb
Protein phosphatase, Mg2+/Mn2+-dependent, 1Nb (putative).
   
  
 0.675
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (14%) [HD]