node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSDARP00000152658 | frmd8 | ENSDARP00000152658 | ENSDARP00000155247 | FERM domain-containing protein. | FERM domain-containing protein 8; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway. | 0.724 |
cdc42ep2 | fam89b | ENSDARP00000070562 | ENSDARP00000116633 | CDC42 effector protein (Rho GTPase-binding) 2. | Family with sequence similarity 89 member B. | 0.834 |
cdc42ep2 | frmd8 | ENSDARP00000070562 | ENSDARP00000155247 | CDC42 effector protein (Rho GTPase-binding) 2. | FERM domain-containing protein 8; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway. | 0.711 |
cdc42ep2 | kcnk7 | ENSDARP00000070562 | ENSDARP00000074419 | CDC42 effector protein (Rho GTPase-binding) 2. | Potassium channel, subfamily K, member 7; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. | 0.854 |
cdc42ep2 | slc25a45 | ENSDARP00000070562 | ENSDARP00000139657 | CDC42 effector protein (Rho GTPase-binding) 2. | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.855 |
cdc42ep2 | znrd2 | ENSDARP00000070562 | ENSDARP00000091074 | CDC42 effector protein (Rho GTPase-binding) 2. | Zinc ribbon domain-containing 2. | 0.752 |
fam89b | cdc42ep2 | ENSDARP00000116633 | ENSDARP00000070562 | Family with sequence similarity 89 member B. | CDC42 effector protein (Rho GTPase-binding) 2. | 0.834 |
fam89b | frmd8 | ENSDARP00000116633 | ENSDARP00000155247 | Family with sequence similarity 89 member B. | FERM domain-containing protein 8; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway. | 0.768 |
fam89b | kcnk7 | ENSDARP00000116633 | ENSDARP00000074419 | Family with sequence similarity 89 member B. | Potassium channel, subfamily K, member 7; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. | 0.861 |
fam89b | slc25a45 | ENSDARP00000116633 | ENSDARP00000139657 | Family with sequence similarity 89 member B. | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.864 |
fam89b | znrd2 | ENSDARP00000116633 | ENSDARP00000091074 | Family with sequence similarity 89 member B. | Zinc ribbon domain-containing 2. | 0.815 |
frmd8 | ENSDARP00000152658 | ENSDARP00000155247 | ENSDARP00000152658 | FERM domain-containing protein 8; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway. | FERM domain-containing protein. | 0.724 |
frmd8 | cdc42ep2 | ENSDARP00000155247 | ENSDARP00000070562 | FERM domain-containing protein 8; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway. | CDC42 effector protein (Rho GTPase-binding) 2. | 0.711 |
frmd8 | fam89b | ENSDARP00000155247 | ENSDARP00000116633 | FERM domain-containing protein 8; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway. | Family with sequence similarity 89 member B. | 0.768 |
frmd8 | itgb1bp1 | ENSDARP00000155247 | ENSDARP00000024965 | FERM domain-containing protein 8; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway. | Integrin beta-1-binding protein 1. | 0.814 |
frmd8 | kcnk7 | ENSDARP00000155247 | ENSDARP00000074419 | FERM domain-containing protein 8; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway. | Potassium channel, subfamily K, member 7; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. | 0.802 |
frmd8 | pbld | ENSDARP00000155247 | ENSDARP00000115236 | FERM domain-containing protein 8; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway. | Phenazine biosynthesis-like protein domain-containing. | 0.718 |
frmd8 | ppm1na | ENSDARP00000155247 | ENSDARP00000011222 | FERM domain-containing protein 8; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway. | Protein phosphatase, Mg2+/Mn2+-dependent, 1Na (putative). | 0.675 |
frmd8 | ppm1nb | ENSDARP00000155247 | ENSDARP00000074081 | FERM domain-containing protein 8; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway. | Protein phosphatase, Mg2+/Mn2+-dependent, 1Nb (putative). | 0.675 |
frmd8 | slc25a45 | ENSDARP00000155247 | ENSDARP00000139657 | FERM domain-containing protein 8; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway. | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.815 |